Molecular targeted therapy: Treating cancer with specificity

European Journal of Pharmacology
Yeuan Ting LeeChern Ein Oon

Abstract

Molecular targeted therapies are revolutionized therapeutics which interfere with specific molecules to block cancer growth, progression, and metastasis. Many molecular targeted therapies approved by the Food and Drug Administration (FDA), have demonstrated remarkable clinical success in the treatment of a myriad of cancer types including breast, leukemia, colorectal, lung, and ovarian cancers. This review provides an update on the different types of molecular targeted therapies used in the treatment of cancer, focusing on the fundamentals of molecular targeted therapy, its mode of action in cancer treatment, as well as its advantages and limitations.

References

Jan 1, 1988·Pharmaceutical Research·F M Brodsky
Jan 17, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Renaud CapdevilleSasa Dimitrijevic
Jan 5, 2005·Nature Reviews. Cancer·Bruce A Chabner, Thomas G Roberts
May 3, 2005·Nature Reviews. Drug Discovery·Daniel C Liebler, F Peter Guengerich
Jan 1, 2008·The Oncologist·Christian WidakowichAhmad Awada
Mar 28, 2008·Expert Opinion on Drug Metabolism & Toxicology·Maria C Shoshan, Stig Linder
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Dec 24, 2008·Nature Reviews. Cancer·Jianming ZhangNathanael S Gray
Jun 6, 2009·Cancer Chemotherapy and Pharmacology·Amalia AzzaritiAngelo Paradiso
Jun 13, 2009·Mini Reviews in Medicinal Chemistry·Travis W Day, Ahmad R Safa
Apr 24, 2010·Nature Reviews. Immunology·Louis M WeinerShangzi Wang
May 22, 2010·The Oncologist·Richard L SchilskyMark McClellan
Jul 24, 2010·Japanese Journal of Clinical Oncology·Nagahiro Saijo
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John H SampsonDarell D Bigner
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Feb 15, 2011·American Journal of Therapeutics·Marijo Bilusic, Ravi A Madan
Jul 14, 2011·Neoplasia : an International Journal for Oncology Research·Hongbo Wang, Chunhong Yan
Mar 24, 2012·Molecular Oncology·Swen HoelderPaul Workman
Jun 12, 2012·MAbs·Niels W C J van de Donk, Eugen Dhimolea
Jun 30, 2012·Science·Martin JinekEmmanuelle Charpentier
Aug 21, 2012·Bioorganic & Medicinal Chemistry Letters·Weiru WangJoachim Rudolph
Sep 25, 2012·Chemistry & Biology·Charles KungLenny Dang
Oct 23, 2012·Toxicologic Pathology·Daniel G Rudmann
Feb 7, 2013·ELife·Martin JinekJennifer Doudna
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Nov 5, 2013·Drug Design, Development and Therapy·Shanchun GuoGuangdi Wang
Dec 4, 2013·Proceedings of the National Academy of Sciences of the United States of America·Elina Zorde KhvalevskyEithan Galun
Mar 25, 2014·Nature Reviews. Cancer·Rudi W HendriksLaurens P Kil
Apr 15, 2014·Progress in Tumor Research·Kenichi Suda, Tetsuya Mitsudomi
May 29, 2014·Cancer Treatment Reviews·Sariah Liu, Razelle Kurzrock
Jun 3, 2014·Breast Cancer Research : BCR·Mark BarokJorma Isola
Jun 4, 2014·Advances in Cancer Research·Jeffrey SchlomJames L Gulley
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Wen XueTyler Jacks
Aug 27, 2014·Basic & Clinical Pharmacology & Toxicology·Gro Vatne Røsland, Agnete Svendsen Tenfjord Engelsen

❮ Previous
Next ❯

Citations

Dec 21, 2018·Omics : a Journal of Integrative Biology·Kevin DzoboM Iqbal Parker
Mar 5, 2019·Journal of Cancer Research and Clinical Oncology·Yasen MaimaitiyimingHua Naranmandura
Jun 21, 2019·Current Topics in Medicinal Chemistry·Zhi-Gang SunYong Qian
Apr 10, 2020·Future Medicinal Chemistry·Yichao WanTingting Liu
Jun 11, 2020·Pharmacogenomics·Elissar MoujaessJoseph Kattan
Jun 13, 2020·Cancers·Praveensingh B HajeriMasato Yamamoto
Apr 6, 2019·AJNR. American Journal of Neuroradiology·A Lasocki, F Gaillard
Aug 21, 2019·International Journal of Molecular Sciences·Keisuke BabaHodaka Fujii
Aug 9, 2020·Frontiers in Cell and Developmental Biology·Daipeng ZhouPeng Xu
Aug 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Michael A Vogelbaum
Jan 2, 2019·Medicines·María Herranz-LópezEnrique Barrajón-Catalán
Jan 11, 2020·Frontiers in Oncology·Daniel HeudoblerAlbrecht Reichle
May 10, 2020·Cell Death & Disease·Kang-Shuai LiHui-Chuan Sun
Sep 29, 2020·Infectious Agents and Cancer·Li WangXiaochun Zhang
Mar 29, 2020·Signal Transduction and Targeted Therapy·Yuan-Hong XieJing-Yuan Fang
Nov 30, 2019·Acta neurochirurgica·Leonard WestermannKourosh Zarghooni
Aug 6, 2020·International Journal of Molecular Sciences·Stefano BurgioCeleste Caruso Bavisotto
Sep 24, 2020·International Journal of Molecular Sciences·Ingrid Lilienthal, Nikolas Herold
Oct 9, 2020·Signal Transduction and Targeted Therapy·Xiaoling SongYingbin Liu
Dec 20, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Brandon MolinaStephanie Grainger
Aug 5, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shangyun LuHongbo Hu
Feb 6, 2020·Seminars in Cancer Biology·Eunus S AliMohammad S Mubarak
Jan 20, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Suhuan MeiXiumin Chen
Oct 5, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Yehuda G AssarafM Helena Vasconcelos

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Therapeutic Approaches

Several different therapeutic approaches are used to treat breast cancer. These include chemotherapy, hormonal therapy, targeted therapy, and Immunotherapy. Discover the latest research on breast cancer therapeutic approaches here.

Related Papers

The Journal of the Christian Medical Association of India
E R HOLLINGBERG
[Rinshō ketsueki] The Japanese journal of clinical hematology
M Hozumi
© 2022 Meta ULC. All rights reserved