Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases.

International Journal of Molecular Sciences
Thanasekaran JayakumarJoen-Rong Sheu

Abstract

Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets th...Continue Reading

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Citations

Feb 13, 2021·Biomolecules·Morgane BourmaudMartine Cohen-Solal
Feb 20, 2021·Journal of Experimental Pharmacology·Gundula Schulze-Tanzil

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Methods Mentioned

BETA
PMA
acetylation
nuclear translocation

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