Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

Frontiers in Cellular and Infection Microbiology
H M Adnan HameedTianyu Zhang

Abstract

Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death worldwide today. Escalating application of genomic techniques has expedited the identification of increasing number of mutations associated with drug resistance in Mycobacterium tuberculosis. Unfortunately the prevalence of bacillary resistance becomes alarming in many parts of the world, with the daunting scenarios of multidrug-resistant tuberculosis (MDR-TB), extensively drug-resistant tuberculosis (XDR-TB) and total drug-resistant tuberculosis (TDR-TB), due to number of resistance pathways, alongside some apparently obscure ones. Recent advances in the understanding of the molecular/ genetic basis of drug targets and drug resistance mechanisms have been steadily made. Intriguing findings through whole genome sequencing and other molecular approaches facilitate the further understanding of biology and pathology of M. tuberculosis for the development of new therapeutics to meet the immense challenge of global health.

References

Feb 25, 1993·The New England Journal of Medicine·T R FriedenS W Dooley
Nov 1, 1995·Antimicrobial Agents and Chemotherapy·K MikusováP J Brennan
Jan 25, 2000·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S Ramaswamy, J M Musser
Jan 18, 2002·Antimicrobial Agents and Chemotherapy·Stephen H Gillespie
Mar 16, 2002·Science·Christopher DyeMario C Raviglione
Dec 31, 2002·The Lancet Infectious Diseases·Ted CohenMegan Murray
Mar 26, 2003·Antimicrobial Agents and Chemotherapy·Srinivas V RamaswamyEdward A Graviss
Mar 30, 2004·Antimicrobial Agents and Chemotherapy·Alexandra AubryEmmanuelle Cambau
Jun 25, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C CavusogluA Bilgic
Aug 9, 2005·The Journal of Pharmacology and Experimental Therapeutics·Lee JiaJoseph E Tomaszewski
Jan 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ujjini H ManjunathaClifton E Barry
Jun 28, 2006·Antimicrobial Agents and Chemotherapy·Nadya Andini, Kevin A Nash
Aug 15, 2006·Nature Medicine·Catherine VilchèzeWilliam R Jacobs
Sep 5, 2006·Respiratory Medicine·Thomas M Daniel
Nov 15, 2006·Antimicrobial Agents and Chemotherapy·Oren ZimhonyWilliam R Jacobs
Mar 3, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C Arnold
Apr 18, 2007·Antimicrobial Agents and Chemotherapy·Xin ShenQian Gao
May 15, 2007·Nature Chemical Biology·Anil KoulKoen Andries
Oct 31, 2007·Journal of Molecular Biology·Divya SharmaRachel Green
Nov 24, 2007·Annual Review of Microbiology·Catherine Vilchèze, William R Jacobs
Nov 30, 2007·Emerging Infectious Diseases·Giovanni Battista MiglioriUNKNOWN SMIRA/TBNET Study Group
Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Doris HillemannElvira Richter
Dec 11, 1948·British Medical Journal·J CROFTON, D A MITCHISON
Mar 5, 2008·Antimicrobial Agents and Chemotherapy·Pontus JuréenSven Hoffner
Jul 25, 2008·Molecular Microbiology·Catherine VilchèzeWilliam R Jacobs
Dec 17, 2008·Antimicrobial Agents and Chemotherapy·Anna C HaagsmaDirk Bald
Dec 17, 2008·Antimicrobial Agents and Chemotherapy·K N WilliamsE Nuermberger
Apr 17, 2009·The Journal of Antimicrobial Chemotherapy·Claire JenkinsTimothy D McHugh
May 14, 2009·The Journal of Biological Chemistry·Sabine GavaldaAnnaïk Quémard

❮ Previous
Next ❯

Citations

Jun 30, 2019·Medicinal Research Reviews·Aparna Bahuguna, Diwan S Rawat
Jan 25, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Md Mahmudul IslamTianyu Zhang
Oct 9, 2019·Journal of Applied Microbiology·R SinghT Prasad
Apr 3, 2020·Chemical Biology & Drug Design·Shasank S SwainTahziba Hussain
Jan 29, 2019·Chemical & Pharmaceutical Bulletin·Jie LiangMing Yan
Jul 19, 2020·Proceedings of the National Academy of Sciences of the United States of America·Trever C SmithBree B Aldridge
Nov 9, 2018·Nature Communications·Christopher N Merrikh, Houra Merrikh
Feb 1, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Prabha DesikanK S Sachdeva
Sep 29, 2020·International Journal of General Medicine·Ali KhodadadianMajid Nazari
Dec 22, 2020·Frontiers in Microbiology·Barbara De SienaMargherita Sacco
Dec 23, 2020·Bioorganic Chemistry·Tejas M DhameliyaAsit K Chakraborti
Dec 17, 2020·Pharmaceutics·Zhi Ming TanHira Choudhury
Dec 31, 2020·Antibiotics·Svetlana G FrolovaDmitry A Maslov
Mar 9, 2021·Journal of Global Antimicrobial Resistance·Saeed KhoshnoodHadi Bazyar
Mar 25, 2021·Revista Da Sociedade Brasileira De Medicina Tropical·Zeng Mei Chun, Jia Qing Jun
Apr 2, 2021·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jian YangJunyang Wang
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phui-Chyng YapHai Yen Lee
May 8, 2021·Frontiers in Pharmacology·Hugo MonteiroRicardo J Ferreira
May 6, 2021·International Journal of Molecular Sciences·Narakorn Khunweeraphong, Karl Kuchler
May 8, 2021·Journal of Medical Microbiology·Andris Evans, Kevin A Kavanagh
May 25, 2021·Computational and Structural Biotechnology Journal·Pooja SinghSeyed E Hasnain
Jun 15, 2021·Journal of Clinical Tuberculosis and Other Mycobacterial Diseases·Sajal Kumar Halder, Fatiha Elma
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Lucie MalaEva Skrivanova
Aug 28, 2021·Antibiotics·Mohd Khairul Nizam MazlanAmirah Mohd Gazzali

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleic acid amplification
genetic modifications

Software Mentioned

Genotype
InterProScan

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.