Molecular Testing in Anatomic Pathology and Adherence to Guidelines: A College of American Pathologists Q-Probes Study of 2230 Testing Events Reported by 26 Institutions

Archives of Pathology & Laboratory Medicine
Keith E VolmarR E Nakhleh

Abstract

The appropriate and timely performance of molecular testing in anatomic pathology is an indicator of quality. The National Comprehensive Cancer Network (NCCN) publishes a comprehensive treatment guideline that includes recommendations for ancillary testing. To establish benchmarks for rates of adherence to NCCN testing recommendations through a multi-institutional study. Participants in a 2013 Q-Probes study of the College of American Pathologists reported data from molecular testing on anatomic pathology cases, excluding hematolymphoid neoplasms, breast primary carcinomas, and gynecologic cytology. Twenty-six institutions reported data from 2230 molecular testing events. In a retrospective study limited to colon, lung, and melanoma, there was strict adherence to guidelines in a median 71% (10th to 90th percentile range, 33%-90%) and there was at least loose adherence in a median 95% (10th to 90th percentile range, 57%-100%). There was adequate tissue to complete testing in a median 98% (10th to 90th percentile range, 86%-100%); in aggregate the adequacy rate for cell blocks was lower (84%, P < .001). Median test turnaround time was 8 days (10th to 90th percentile range, 4-13 days). In a prospective collection of all organ site...Continue Reading

References

Jan 7, 2009·Genetics in Medicine : Official Journal of the American College of Medical Genetics·UNKNOWN Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
Jan 13, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Cecelia A BellcrossMuin J Khoury
Feb 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura C BeamerDeborah J MacDonald

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Citations

Nov 30, 2016·Expert Review of Molecular Diagnostics·Michelangelo FiorentinoRodolfo Montironi
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L Hunt
Jun 17, 2018·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Ridgely Fisk GreenMuin J Khoury

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