Molecular testing in lung cancer: the time is now.

Current Oncology Reports
Haiying ChengBalazs Halmos

Abstract

In the past few years, we have witnessed a revolution in the molecular understanding of non-small cell lung cancer. Major progress has also been made in the clinic, with the introduction of EGFR-targeted and anti-angiogenic therapies. These advances have led to the development of a multitude of commercially available prognostic and predictive biomarkers. In particular, EGFR mutation and EML4/ALK testing have reached clinical validation and are incorporated into current treatment paradigms. This overview will present the scientific background of the biology of the relevant biomarkers and the studies conducted for their clinical validation. The technical challenges and shortcomings of these assays are also discussed. Furthermore, ongoing biomarker-driven clinical studies and the appropriate clinical use of available tests will be reviewed to assist the clinician with the proper incorporation of molecular testing into the routine care of patients with non-small cell lung cancer.

References

Aug 30, 1990·The New England Journal of Medicine·R J SlebosW J Mooi
Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Feb 24, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vincent A MillerRobert T Heelan
May 15, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerold BeplerLary Robinson
Feb 25, 2005·The New England Journal of Medicine·Susumu KobayashiBalázs Halmos
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Jun 24, 2005·The New England Journal of Medicine·Timothy WintonUNKNOWN National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators
Aug 11, 2006·The New England Journal of Medicine·Anil PottiJoseph R Nevins
Sep 8, 2006·The New England Journal of Medicine·Ken A OlaussenUNKNOWN IALT Bio Investigators
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gerold BeplerGeorge Simon
Nov 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R HirschBrian Holloway
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Feb 23, 2007·The New England Journal of Medicine·Zhong ZhengGerold Bepler
Feb 24, 2007·Nature Reviews. Cancer·Sreenath V SharmaDaniel A Haber
Apr 10, 2007·International Journal of Cancer. Journal International Du Cancer·Tomoyoshi TakenakaYoshihiko Maehara
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George SimonGerold Bepler
Jul 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Manuel CoboRafael Rosell
Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kentaro InamuraYuichi Ishikawa
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David A EberhardUNKNOWN Non-Small-Cell Lung Cancer Working Group
Mar 14, 2008·The New England Journal of Medicine·Fortunato Ciardiello, Giampaolo Tortora
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giorgio Vittorio ScagliottiDavid Gandara
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jussi P KoivunenPasi A Jänne
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Jul 16, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chang-Qi ZhuUNKNOWN National Cancer Institute of Canada Clinical Trials Group Study BR.21
Jul 22, 2008·Nature Medicine·UNKNOWN Director's Challenge Consortium for the Molecular Classification of Lung AdenocarcinomaDavid G Beer
Oct 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Gerold BeplerLary A Robinson
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luca Toschi, Pasi A Jänne
Oct 7, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CappuzzoM Varella-Garcia
Nov 4, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Koichi AzumaHisamichi Aizawa
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Manabu SodaHiroyuki Mano
Mar 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federico CappuzzoMarileila Varella-Garcia

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Citations

Aug 2, 2011·American Journal of Respiratory and Critical Care Medicine·Balazs Halmos, Charles A Powell
Sep 10, 2011·Therapeutic Advances in Medical Oncology·Elizabeth M Gaughan, Daniel B Costa
Jul 22, 2011·Pathology Research International·Adnan HasanovicAndre L Moreira
Aug 21, 2013·American Journal of Respiratory and Critical Care Medicine·Mina GagaUNKNOWN ATS/ERS Task Force on the Role of the Pulmonologist in the Management of Lung Cancer
Jan 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Janakiraman SubramanianRamaswamy Govindan
Aug 23, 2012·American Journal of Clinical Pathology·Dara L Aisner, Carrie B Marshall
Apr 12, 2011·Journal of Surgical Oncology·David Berz, Harold Wanebo
Aug 4, 2016·Cancer Medicine·Masatoshi ShionoSwarnali Acharyya

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