Conventional temperature measurements rely on material responses to heat, which can be detected visually. When Galileo developed an air expansion based device to detect temperature changes, Santorio, a contemporary physician, added a scale to create the first thermometer. With this instrument, patients' temperatures could be measured, recorded, and related to changing health conditions. Today, advances in materials science and bioengineering provide new ways to report temperature at the molecular level in real time. In this review, the scientific foundations and history of thermometry underpin a discussion of the discoveries emerging from the field of molecular thermometry. Intracellular nanogels and heat sensing biomolecules have been shown to accurately report temperature changes at the nanoscale. Various systems will soon provide the ability to accurately measure temperature changes at the tissue, cellular, and even subcellular level, allowing for detection and monitoring of very small changes in local temperature. In the clinic, this will lead to enhanced detection of tumors and localized infection, and accurate and precise monitoring of hyperthermia-based therapies. Some nanomaterial systems have even demonstrated a theran...Continue Reading
Cryothermal ablation: mechanism of tissue injury and current experience in the treatment of tachyarrhythmias
Cryopreserved human haematopoietic stem cells retain engraftment potential after extended (5-14 years) cryostorage
Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm
Construction and characterization of thermo-inducible vectors derived from heat-sensitive lacI genes in combination with the T7 A1 promoter
Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects
Intracellular temperature mapping with a fluorescent polymeric thermometer and fluorescence lifetime imaging microscopy
Thermoresponsive interplay of water insoluble poly(2-alkyl-2-oxazoline)s composition and supramolecular host-guest interactions
A cationic fluorescent polymeric thermometer for the ratiometric sensing of intracellular temperature
Intracellular Temperature Sensing: An Ultra-bright Luminescent Nanothermometer with Non-sensitivity to pH and Ionic Strength
Upconversion luminescent nanoparticles in physical sensing and in monitoring physical processes in biological samples
Measurement of local temperature increments induced by cultured HepG2 cells with micro-thermocouples in a thermally stabilized system
A simple yet effective AIE-based fluorescent nano-thermometer for temperature mapping in living cells using fluorescence lifetime imaging microscopy
An engineered thermo-sensitive nanohybrid particle for accurate temperature sensing at the single-cell level and biologically controlled thermal therapy
Ratiometric highly sensitive luminescent nanothermometers working in the room temperature range. Applications to heat propagation in nanofluids
Luminescent Yb3+,Er3+-Doped α-La(IO3)3 Nanocrystals for Neuronal Network Bio-Imaging and Nanothermometry.
Luminescent PMMA Films and PMMA@SiO2 Nanoparticles with Embedded Ln3+ Complexes for Highly Sensitive Optical Thermometers in the Physiological Temperature Range*.
Lanthanide doped luminescence nanothermometers in the biological windows: strategies and applications.
Isostructural Tb3+ /Eu3+ Co-Doped Metal-Organic Framework Based on Pyridine-Containing Dicarboxylate Ligands for Ratiometric Luminescence Temperature Sensing
Measurement of Temperature Distribution at the Nanoscale with Luminescent Probes Based on Lanthanide Nanoparticles and Quantum Dots
L-DNA molecular beacon: a safe, stable, and accurate intracellular nano-thermometer for temperature sensing in living cells
Biosensors for Cancer Detection
Biosensors are devices that are designed to detect a specific biological analyte by essentially converting a biological entity (ie, protein, DNA, RNA) into an electrical signal that can be detected and analyzed. The use of biosensors in cancer detection and monitoring holds vast potential. Biosensors can be designed to detect emerging cancer biomarkers and to determine drug effectiveness at various target sites. Biosensor technology has the potential to provide fast and accurate detection, reliable imaging of cancer cells, and monitoring of angiogenesis and cancer metastasis, and the ability to determine the effectiveness of anticancer chemotherapy agents.