Molecular thermometry

Pediatric Research
Kevin M McCabe, Mark Hernandez


Conventional temperature measurements rely on material responses to heat, which can be detected visually. When Galileo developed an air expansion based device to detect temperature changes, Santorio, a contemporary physician, added a scale to create the first thermometer. With this instrument, patients' temperatures could be measured, recorded, and related to changing health conditions. Today, advances in materials science and bioengineering provide new ways to report temperature at the molecular level in real time. In this review, the scientific foundations and history of thermometry underpin a discussion of the discoveries emerging from the field of molecular thermometry. Intracellular nanogels and heat sensing biomolecules have been shown to accurately report temperature changes at the nanoscale. Various systems will soon provide the ability to accurately measure temperature changes at the tissue, cellular, and even subcellular level, allowing for detection and monitoring of very small changes in local temperature. In the clinic, this will lead to enhanced detection of tumors and localized infection, and accurate and precise monitoring of hyperthermia-based therapies. Some nanomaterial systems have even demonstrated a theran...Continue Reading


Oct 1, 1985·Cryobiology·J A DonovanP M Loh
Jan 1, 1981·Scientific American·T Tanaka
Aug 13, 1999·Progress in Cardiovascular Diseases·D L LustgartenJ Ruskin
May 1, 2001·Physical Review Letters·J L RobertsC E Wieman
Jul 19, 2001·Nature·E A DonleyC E Wieman
Oct 3, 2001·Physical Review Letters·P BorriD Bimberg
Mar 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·M FRIED
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ghadiyaram ChakshusmathiRaghavan Varadarajan
Jan 22, 2005·Annual Review of Medicine·Shahid M NimjeeBruce A Sullenger
Jul 12, 2005·Annual Review of Biomedical Engineering·A Paul AlivisatosCarolyn Larabell
Jan 28, 2006·FEMS Microbiology Reviews·Franz NarberhausSaheli Chowdhury
May 20, 2006·The EMBO Journal·Saheli ChowdhuryFranz Narberhaus
Sep 1, 2007·European Journal of Pediatrics·Amulya K Saxena, Günter H Willital
Feb 10, 2009·Journal of the American Chemical Society·Chie GotaSeiichi Uchiyama
Aug 8, 2009·Physics in Medicine and Biology·Melanie KetteringIngrid Hilger

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Mar 8, 2011·Applied and Environmental Microbiology·K M McCabeM Hernandez
Feb 2, 2010·Pediatric Research·Edward R B McCabe
May 15, 2013·Sensors·Anette Thyssen JonstrupAnni Hangaard Andersen
Apr 8, 2015·International Journal of Molecular Sciences·Victor R de la RosaRichard Hoogenboom
Oct 13, 2010·Advanced Drug Delivery Reviews·J Andrew MacKay, Zibo Li
Apr 5, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Antonin SoleilhacRodolphe Antoine
Sep 12, 2017·Chemical Communications : Chem Comm·Seiichi UchiyamaNoriko Inada
Jul 6, 2012·Nanoscale·Carlos D S BritesLuís D Carlos
Sep 17, 2013·Angewandte Chemie·Li ShangG Ulrich Nienhaus
Nov 5, 2019·PLoS Computational Biology·Rachel HowardRobert Gatenby
Apr 30, 2016·Nanotechnology·M A Cardona-CastroJ Alvarez-Quintana
Sep 23, 2020·Nanoscale Research Letters·Lazo Jazaa Mohammed, Khalid M Omer
Oct 1, 2015·Methods and Applications in Fluorescence·María González-Béjar, Julia Pérez-Prieto
Mar 15, 2019·Biomicrofluidics·Fan YangShengyong Xu
Mar 3, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Hui GaoSijie Chen
Dec 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Fangyuan DongYang Tian
Jul 22, 2014·Chemistry : a European Journal·Natalia G ZhegalovaMikhail Y Berezin
May 18, 2019·Mikrochimica Acta·Hailiang ZhangWenbin Zeng
Mar 28, 2019·Acta Cirúrgica Brasileira·Leonardo Waldstein de Moura VidalAndré Lacerda de Abreu Oliveira
Feb 13, 2021·Materials·Bong Han LeeAnton V Naumov
Feb 5, 2021·Chemistry : a European Journal·Flore Vanden BusscheChristian V Stevens
Aug 31, 2011·Journal of the American Chemical Society·Emily J McLaurinDaniel R Gamelin
Nov 7, 2012·Journal of the American Chemical Society·Guoliang KeChaoyong James Yang
Aug 14, 2020·The Journal of Physical Chemistry Letters·Benjamin FigueroaDan Fu

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