Molecular toggle switch of histone demethylase LSD1

Molecular Cell
Jaehoon ShinHongjun Song

Abstract

In this issue of Molecular Cell, Laurent et al. (2015) demonstrated that a neuron-enriched isoform of LSD1 (LSD1+8a) within a SVIL-containing complex exhibits H3K9me1/2-specific demethylation activity. Such activity was crucial for gene activation during mammalian neurogenesis.

References

Mar 18, 2008·Trends in Biochemical Sciences·Federico FornerisAndrea Mattevi

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Citations

Dec 10, 2015·Epigenomics·Xueshun WangPeng Zhan
Jun 23, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Monique G P van der WijstMarianne G Rots
Apr 7, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruizhong FangFeng Tian

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