PMID: 8982375Dec 1, 1996Paper

Molecular variants of fibronectin and laminin: structure, physiological occurrence and histopathological aspects

Virchows Archiv : an International Journal of Pathology
H KosmehlDetlef Katenkamp

Abstract

This review deals with biological and pathological aspects of various isoforms of the matrix molecules fibronectin and laminin. They are generated by different molecular mechanisms: ED-A+ and ED-B+ fibronectin by alternative splicing of pre mRNA, de novo-glycosylated fibronectin by alternative post-translational O-linked glycosylation of the IIICS region, and the laminin isoforms by exchange of single chains of the heterotrimeric molecule. In contrast to the "common" fibronectin, the distribution of ED-B+ and de novo-glycosylated fibronectin is restricted to embryonic tissues; they subsequently reappear in granulation tissue, in fibrosing processes and in tumour stroma. The expression of these so-called oncofetal fibronectins is stimulated by growth factors (TGF beta). The association of the ED-B+ fibronectin with proliferative activity and newly formed vessels identifies this fibronectin variant as a marker of cellular activity in the process of fibrosis and as a suitable agent for the evaluation of tumour angioneogenesis. Initial results suggest a correlation between the amount of ED-B+ and de novo-glycosylated fibronectin in tumour stroma and the behaviour of carcinomas with regard to their invasiveness and propensity for me...Continue Reading

Citations

Apr 4, 2008·Journal of Cancer Research and Clinical Oncology·Petra RichterHeiko Wunderlich
Jun 22, 2006·Mund-, Kiefer- und Gesichtschirurgie : MKG·Oliver DriemelH Kosmehl
May 13, 1999·Progress in Histochemistry and Cytochemistry·K Ostergaard, D M Salter
Aug 21, 2013·Cell Death & Disease·J SassoneA Ciammola
Jan 5, 2001·British Journal of Pharmacology·V M ManzanoF J Cazaña
Aug 10, 2000·Histopathology·N Patey-Mariaud De SerreN Brousse
Jul 28, 2009·The Journal of Biological Chemistry·Elisa VenturaLuciano Zardi
Jul 21, 2000·Endocrine-related Cancer·R K Hansen, M J Bissell
May 8, 2013·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Jiji GeorgeNirmala N Rao
Aug 3, 2014·Advanced Drug Delivery Reviews·Hao HongWeibo Cai
Dec 8, 2015·Advanced Drug Delivery Reviews·Heena Kumra, Dieter P Reinhardt
May 30, 2009·International Journal of Cancer. Journal International Du Cancer·Enrica BalzaLaura Borsi
Dec 22, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marcus FranzAlexander Berndt
Nov 23, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·O DriemelH Kosmehl
Sep 8, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Petra RichterAlexander Berndt
Feb 9, 2016·The Journal of Investigative Dermatology·Bum-Ho BinEun-Gyung Cho
Nov 6, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Marcus FranzAlexander Berndt
Sep 19, 2006·Biomaterials·David Richard Schmidt, Weiyuan John Kao
Jun 20, 2006·Journal of Biochemical and Biophysical Methods·Agnes PatakiIstván Kurucz
Dec 12, 2001·The British Journal of Oral & Maxillofacial Surgery·A J LyonsU Mandel
May 23, 1998·Experimental Cell Research·L BorsiL Zardi
Jul 22, 1999·Experimental Cell Research·G Serini, G Gabbiani
Apr 18, 2003·Metabolism: Clinical and Experimental·Robert W PowersJames M Roberts

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