PMID: 9646031Jul 1, 1998Paper

Molecular variants of the EWS-WT1 gene fusion in desmoplastic small round cell tumor

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
C R AntonescuM Ladanyi

Abstract

We report two cases of desmoplastic small round cell tumor (DSRCT) with novel molecular variants of the specific EWS-WT1 gene fusion. This fusion usually encodes a chimeric RNA with an in-frame junction of exon 7 of EWS to exon 8 of WT1. In one variant patient, the EWS-WT1 fusion transcript contained an in-frame junction of exon 9 of EWS to exon 8 of WT1. Moreover, in this patient the tumor arose in the hand, an extremely unusual site for DSRCT. In the second patient, an in-frame junction of exon 10 of EWS to exon 8 of WT1 was present. These two cases of DSRCT show that the molecular variability in the EWS breakpoint observed in the EWS-FLI1 fusion of Ewing's sarcoma can occur in DSRCT as well. This type of heterogeneity is relevant to the interpretation of molecular diagnostic assays and could also affect the functional properties of the encoded chimeric transcription factors.

References

Sep 1, 1995·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·M Ladanyi
Feb 15, 1995·JAMA : the Journal of the American Medical Association·F G BarrR B Womer
Feb 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·W L GeraldM Ladanyi
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·W A MayC T Denny
Dec 1, 1995·Human Pathology·S G BrodieT M Williams
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H KushnerW L Gerald
Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ZoubekH Kovar
Feb 1, 1996·Seminars in Cancer Biology·P H Sorensen, T J Triche
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E de AlavaM Ladanyi

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Citations

Jul 24, 2003·The Journal of Molecular Diagnostics : JMD·Chung-Che Chang, Vinod B Shidham
Apr 10, 2014·International Journal of Molecular Medicine·Margherita CerroneGerardo Botti
May 1, 2007·Journal of Clinical Pathology·Olga Slater, Janet Shipley
Oct 16, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kyung-Ja ChoSang Yoon Kim
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Maria TsokosPaul S Dickman
Feb 2, 2002·Current Oncology Reports·Stephen J Qualman, Raffaella A Morotti
Dec 1, 2012·Surgical Pathology Clinics·Robin D LeGallo
Sep 1, 2011·Surgical Pathology Clinics·Khin Thway
Aug 26, 2006·Pathology International·Minoru HamazakiTaemi Nara
Mar 26, 2015·Future Oncology·Jaume MoraJuan Rosai
May 8, 2014·The International Journal of Biochemistry & Cell Biology·Adrián Mariño-Enríquez, Christopher D M Fletcher
Jun 18, 2016·Seminars in Diagnostic Pathology·Enrique de Alava, David Marcilla
Mar 6, 2009·Virchows Archiv : an International Journal of Pathology·Luciano NederFredric B Meyer
Jul 27, 2001·International Journal of Surgical Pathology·E de Alava, J Pardo
Jan 1, 2003·Genes, Chromosomes & Cancer·Haim Werner, Charles T Roberts
Aug 10, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Javal ShethGino R Somers
Sep 17, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marta López-FragaAna Jiménez
Nov 11, 1999·The American Journal of Surgical Pathology·V AdsayJ Rosai
Jun 4, 2002·Acta Cytologica·Luigi InsabatoGuido Pettinato
Sep 10, 2002·Journal of Computer Assisted Tomography·Ukihide TateishiNoriyuki Moriyama
Jul 23, 1999·Current Opinion in Oncology·J L Bennicelli, F G Barr
Sep 8, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·A Llombart-BoschA Peydró-Olaya
May 30, 2001·Cancer Control : Journal of the Moffitt Cancer Center·G D Letson, C A Muro-Cacho
Nov 4, 2016·International Journal of Surgical Pathology·Khin ThwayCyril Fisher
Dec 14, 2018·International Journal of Surgical Pathology·Alyaa Al-IbraheemiKaren J Fritchie
Jun 1, 2018·JCO Precision Oncology·Ajaz BulbulHatim Husain
Jul 20, 2002·The American Journal of Surgical Pathology·Marick E LaeAntonio G Nascimento
Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jun NishioMasahiro Kikuchi

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