Molecular virology of the hepatitis C virus: implication for novel therapies

Infectious Disease Clinics of North America
Jeffrey S Glenn

Abstract

With the advent of second-generation agents that for the first time specifically target individual HCV proteins, HCV-specific therapy has arrived. The study of HCV molecular virology has helped make this possible and is helping us to identify additional new antiviral targets that will be targeted by third-generation drugs. Key to these efforts is the development of high-efficiency HCV replicons. The future effective pharmacologic control of HCV will likely consist of a cocktail of simultaneously administered virus-specific agents with independent targets. This should minimize the emergence of resistance against any single agent. The way we treat HCV should change dramatically over the next few years.

References

Mar 15, 1996·The Journal of Biological Chemistry·C SteinkühlerR De Francesco
Oct 30, 1998·Science·P PileriS Abrignani
Aug 19, 1999·The New England Journal of Medicine·M J AlterH S Margolis
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·V AgnelloQ X Zhang
Jan 13, 2000·Biochemical and Biophysical Research Communications·J S ParkM K Min
Feb 19, 2000·Annals of Internal Medicine·T J LiangJ H Hoofnagle
Mar 25, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A M Di Bisceglie
Dec 7, 2000·The New England Journal of Medicine·S ZeuzemM J Brunda
Dec 9, 2000·Science·K J BlightC M Rice
Mar 22, 2002·Journal of Virology·Thomas PietschmannRalf Bartenschlager
Jun 18, 2002·The EMBO Journal·Laurence CocquerelJean Dubuisson
Nov 20, 2002·Journal of Virology·Keril J BlightCharles M Rice
Jan 30, 2003·The Journal of Biological Chemistry·Baohua GuRobert T Sarisky
Mar 5, 2003·The Journal of Experimental Medicine·Birke BartoschFrançois-Loïc Cosset
Apr 15, 2003·Journal of Virology·Marika LundinMats A A Persson
Apr 30, 2003·Journal of Virology·Menashe ElazarJeffrey S Glenn
Jun 10, 2003·Microbiology and Molecular Biology Reviews : MMBR·Nathalie Chazal, Denis Gerlier
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Akito SakaiJens Bukh
Nov 14, 2003·The Journal of Antimicrobial Chemotherapy·Shirit Einav, Jeffrey S Glenn
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jin YeMichael Gale

❮ Previous
Next ❯

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Jeffrey S Glenn
Liver International : Official Journal of the International Association for the Study of the Liver
Yonghong ZhangXinyue Chen
World Journal of Gastroenterology : WJG
Anna ParfieniukRobert Flisiak
© 2021 Meta ULC. All rights reserved