Molecular weight (hydrodynamic volume) dictates the systemic pharmacokinetics and tumour disposition of PolyPEG star polymers

Nanomedicine : Nanotechnology, Biology, and Medicine
Song Yang KhorThomas P Davis

Abstract

Herein we report for the first time the biological fate of poly[(oligoethylene glycol) acrylate] (POEGA) star polymers synthesised via a versatile arm-first reversible addition-fragmentation chain transfer (RAFT) polymerisation approach. The biopharmaceutical behaviour of three different molecular weight (49, 64 and 94kDa) POEGA stars was evaluated in rats and nude mice bearing human MDA MB-231 tumours after intravenous administration. The 94kDa star polymer exhibited a longer plasma exposure time than the 49kDa or 64kDa star polymer; an observation attributable to differences in the rates of both polymer biodegradation and urinary excretion. Tumour biodistribution also correlated with molecular weight and was greatest for the longest circulating 94kDa star. Different patterns of liver and spleen biodistribution were observed between mice and rats for the different sized polymers. The polymers were also well-tolerated in vivo and in vitro at therapeutic concentrations. Advances in nanotechnology has enabled scientists to produce nanoparticle as drug carriers in cancer therapeutics. In this article, the authors studied the biological fate of poly[(oligoethylene glycol) acrylate] (POEGA) star polymers of different size, after int...Continue Reading

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Citations

Mar 25, 2017·ACS Applied Materials & Interfaces·Joshua J GlassStephen J Kent
Mar 26, 2019·Pharmaceutical Nanotechnology·Reza Baradaran EftekhariFarid Abedin Dorkoosh
Sep 13, 2017·Macromolecular Rapid Communications·Da-Peng YangXian Jun Loh
Mar 7, 2020·Nuclear Medicine and Biology·Jeroen A C M GoosJason S Lewis
Jun 13, 2021·Macromolecular Bioscience·Hui Wen Yong, Ashok Kakkar

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