PMID: 9434867Jan 22, 1998Paper

Molecular/cellular biology of the heat stress response and its role in agent-induced teratogenesis

Mutation Research
P E Mirkes

Abstract

Available data indicate that heat shock proteins act as chaperones under non-stress conditions by assisting in: (1) the folding of newly synthesized proteins, (2) the intracellular translocation of proteins, and (3) the function of other proteins. As we gain additional information concerning cellular physiology, we may find that heat shock proteins play a key role in many additional cellular functions. When cells experience thermal or chemical stress, heat shock proteins take on a new role, conserved from bacteria to humans, of protecting cells from the detrimental effects of stress. This latter role takes on added significance for the embryo in which the developmental program must be read linearly, with little opportunity to cycle backward to complete a missed segment of the program. Although circumstantial evidence clearly implicates heat shock proteins in protecting embryos from thermal stress, definitive evidence is still lacking. The challenge for the future is to obtain such definitive data. Ideally, such information will lead to new therapeutic paradigms that will afford protection to the human embryo/fetus exposed to thermal/chemical stress.

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Citations

Jan 22, 1998·Mutation Research·L R Ferguson, J H Ford
Sep 16, 2000·Animal Reproduction Science·Y T KingY H Kuo
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Natsumi SakamotoYukio Kanai
Dec 15, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Daniel I StefanovicRichard G Manzon
Jun 15, 2010·Birth Defects Research. Part C, Embryo Today : Reviews·Peter G Alexander, Rocky S Tuan
Aug 22, 2016·Comptes rendus biologies·Palma SimonielloRosaria Scudiero
Apr 26, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Andrew E CzeizelFerenc Bánhidy
Sep 19, 2002·Radiation Research·D R BorehamR E J Mitchel
Feb 6, 2018·Scientific Reports·Ohad Cohen, Samuel A Safran
Feb 8, 2002·World Journal of Gastroenterology : WJG·Ben-Yan ZhangGuo-Gao Zhang

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