Molecularly imprinted nanoparticles prepared by miniemulsion polymerization as selective receptors and new carriers for the sustained release of carbamazepine.

Journal of Materials Science. Materials in Medicine
Mehdi Esfandyari-ManeshFatemeh Atyabi

Abstract

Water-compatible imprinted nanoparticles were prepared for carbamazepine as a template and used for the selective extraction and controlled release of carbamazepine. Assay materials and drug delivery carriers were typically used in aqueous environments, so it is generally preferable to prepare solvent-free molecularly imprinted nanoparticles in water using the miniemulsion polymerization method. The present work investigates a bio-analytical strategy generically applicable to imprinted materials for molecular recognition studies, including equilibrium and non-equilibrium binding, and release experiments, increasing the knowledge of the molecular interactions between the template molecules and imprinted nanoparticles. The results showed that the imprinted nanoparticles exhibited a higher binding level and slower release rate than non-imprinted nanoparticles. The selectivity of imprinted nanoparticles for carbamazepine studied in comparison with an analogue compound, oxcarbazepine, the main metabolite of carbamazepine. The recovery and selectivity of carbamazepine in human serum was determined to be 100%, 1.7 times that of oxcarbazepine. The results indicated that carbamazepine-imprinted nanoparticles are appropriate for serum le...Continue Reading

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Citations

Aug 16, 2013·Analytical Chemistry·Romana Schirhagl
Jun 15, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Maryam ShekarchiRassoul Dinarvand
Dec 3, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Mojgan PourfarzibRassoul Dinarvand
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Mehdi Esfandyari-ManeshFatemeh Atyabi
Sep 22, 2015·Physical Chemistry Chemical Physics : PCCP·Fangfang ChenJie Kong
Mar 15, 2015·Frontiers in Bioengineering and Biotechnology·Barbara Sanavio, Silke Krol
Jan 11, 2017·Scientific Reports·Mariacristina GagliardiAngelo Bifone
Nov 26, 2013·Nanomaterials·Muhammad IrshadMuhammad Makshoof Athar
Apr 25, 2019·Macromolecular Bioscience·Ratchapol JenjobDaniel Crespy
May 16, 2019·Advanced Materials·Huiqi Zhang
Oct 2, 2020·BioTechniques·Zahra El-SchichAnette Gjörloff Wingren
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mona QushawyAli Nasr

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