Molecularly imprinted polymer functionalized silica nanoparticles for enantioseparation of racemic tryptophan in aqueous solution

Mikrochimica Acta
Ling LiLi Jia

Abstract

A method has been developed for preparation of surface molecularly imprinted polymer functionalized silica nanoparticles (SiO2@MPS@MIP). Firstly, the silica nanoparticles are prepared by a one-pot sol-gel method using tetraethylorthosilicate and 3-methacryloxypropyltrimethoxysilane as functional monomers. Next, the template molecule (L-Trp) is self-assembled with the functional monomer (acrylamide). Finally, SiO2@MPS@MIP are prepared using N,N'-methylenebisacrylamide as the cross-linker. The prepared SiO2@MPS@MIP have an average diameter of about 6.3 ± 1.2 nm. They exhibit good selectivity toward L-Trp with an imprinting factor of 6.3. The adsorption isotherm data was well described by the Langmuir model. The maximum adsorption capacities of SiO2@MPS@MIP for L-Trp and D-Trp were calculated to be 11.1 ± 0.9 and 2.66 ± 0.16 mg g-1, respectively. An enantiomer excess value of 100% was achieved after adsorption of racemic Trp by the material. The work suggests that SiO2@MPS@MIP are a promising material for enantioseparation of Trp racemate in aqueous media. Graphical abstract.

References

Feb 22, 2012·Journal of Pharmaceutical and Biomedical Analysis·István IliszAntal Péter
Feb 7, 2013·Colloids and Surfaces. B, Biointerfaces·Sudipa GhoshK Hidajat
Feb 11, 2015·Journal of Colloid and Interface Science·M MonierHossam M Nassef
May 10, 2016·Journal of Pharmaceutical and Biomedical Analysis·Sven DeclerckDebby Mangelings
Aug 3, 2018·Journal of Colloid and Interface Science·Raedah A S AlatawiNadia H Elsayed

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