Molecularly Imprinted Porous Aromatic Frameworks Serving as Porous Artificial Enzymes

Advanced Materials
Ye YuanGuangshan Zhu

Abstract

Artificially designed enzymes are in demand as ideal catalysts for industrial production but their dense structure conceals most of their functional fragments, thus detracting from performance. Here, molecularly imprinted porous aromatic frameworks (MIPAFs) which are exploited to incorporate full host-guest interactions of porous materials within the artificial enzymes are presented. By decorating a porous skeleton with molecularly imprinted complexes, it is demonstrated that MIPAFs are porous artificial enzymes possessing excellent kinetics for guest molecules. In addition, due to the abundance of accessible sites, MIPAFs can perform a wide range of sequential processes such as substrate hydrolysis and product transport. Through its two functional sites in tandem, the MIPAF subsequently manifests both hydrolysis and transport behaviors. Advantageously, the obtained catalytic rate is ≈58 times higher than that of all other conventional artificial enzymes and even surpasses by 14 times the rate for natural organophosphorus hydrolase (Flavobacterium sp. strain ATCC 27551).

References

Jul 26, 1976·Biochemical and Biophysical Research Communications·M P UitendaalP Hösli
Nov 19, 2005·Science·Adrien P CôtéOmar M Yaghi
May 27, 2008·Journal of the American Chemical Society·Jia-Xing JiangAndrew I Cooper
Oct 27, 2009·Nature Materials·Tomokazu TozawaAndrew I Cooper
Apr 9, 2011·Science·John W ColsonWilliam R Dichtel
Jun 17, 2011·Nature·James T A JonesAndrew I Cooper
Jan 6, 2012·Chemical Communications : Chem Comm·Kai YaoShichang Wang
Dec 25, 2013·Chemical Society Reviews·Matthieu RaynalPiet W N M van Leeuwen
Oct 28, 2015·Chemical Society Reviews·Qi SunFeng-Shou Xiao
Mar 5, 2016·Applied Microbiology and Biotechnology·Ilya V LyaginElena N Efremenko
Mar 5, 2016·Chemical Society Reviews·Lingxin ChenJinhua Li
Apr 5, 2016·Nature Materials·Hong XuDonglin Jiang
Dec 3, 2016·Chemical Society Reviews·Xiao-Yu YangBao-Lian Su
Mar 28, 2017·Journal of the American Chemical Society·Zijie ZhangJuewen Liu

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Citations

May 17, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Ying-Hua ZhouJing Gu
May 14, 2020·Sensors·Aysu Yarman, Frieder W Scheller
Dec 26, 2018·Advanced Science·Shuaihua ZhangYusuke Yamauchi
Aug 14, 2020·Journal of the American Chemical Society·Minghua LiShaojun Dong
Jul 30, 2020·ACS Central Science·Ye YuanGuangshan Zhu
Jan 6, 2021·The Journal of Organic Chemistry·Ishani BoseYan Zhao
Dec 12, 2018·ACS Applied Materials & Interfaces·Xiaohui XuHexiang Deng
Apr 3, 2019·ACS Central Science·Ye Yuan, Guangshan Zhu
Feb 27, 2020·Chemical Reviews·Yuyang Tian, Guangshan Zhu
Nov 9, 2021·The Journal of Physical Chemistry Letters·Enpeng XiGuangshan Zhu

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