Abstract
Large, randomized trials have been conducted in the primary prevention of lung cancer using micronutrients or derivative agents for which epidemiological data suggested a potential role in lung cancer prevention. The disappointing primary prevention trials of beta-carotene, alpha-tocopherol, and retinyl palmitate have led to the development of a more compact, biomarker-driven series of translational trials of lung cancer prevention that target reversal of premalignancy as the primary end point. Serial trials of 13-cis-retinoic acid (isotretinoin) and other retinoids have failed to show a difference in reversal of premalignancy in active smokers or in second primary tumor prevention. However, a trial of 9-cis-retinoic acid, a pan retinoid/rexinoid agonist, showed up-regulation of retinoic acid receptor beta (RAR-beta), a potentially important intermediate marker of response in lung cancer premalignancy. Other planned or ongoing trials currently target important molecular markers of lung carcinogenesis and progression including cyclooxygenase-2, the ras-signaling pathway through farnesyl transferase inhibitors, and the tyrosine kinase/epidermal growth factor receptor pathway (gefitinib, erlotinib). Early results of bioadjuvant tr...Continue Reading
References
May 1, 1992·British Journal of Cancer·A M ArnoldM Newhouse
Sep 20, 1990·The New England Journal of Medicine·W K HongL J Peters
Dec 11, 1986·The New England Journal of Medicine·W K HongC Vaughan
Dec 1, 1995·The American Journal of Clinical Nutrition·J W McLartyS D Greenberg
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LeeH A Fritsche
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U PastorinoM Valente
May 2, 1996·The New England Journal of Medicine·C H HennekensR Peto
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
Jun 18, 1997·Journal of the National Cancer Institute·L MaoW K Hong
Oct 6, 1997·Journal of the National Cancer Institute·I I WistubaA F Gazdar
Jun 22, 2000·Journal of the National Cancer Institute·N van ZandwijkH van Tinteren
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R KhuriX C Xu
Apr 20, 2001·Journal of the National Cancer Institute·S M LippmanW K Hong
Jan 29, 2003·Cancer Metastasis Reviews·Victor Cohen, Fadlo R Khuri
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 6, 2003·Journal of the National Cancer Institute·Jonathan M KurieWaun Ki Hong
Aug 10, 1961·The New England Journal of Medicine·O AUERBACHL GARFINKEL
Citations
Nov 12, 2003·Clinical Lung Cancer·Angelia D Gibson
Nov 1, 2007·Journal of the National Cancer Institute·Walter N HittelmanJ Jack Lee
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R M Ruhul AminDong M Shin
May 21, 2014·Cancers·Hasmeena KathuriaKatrina Steiling
Jul 17, 2009·Journal of Receptor and Signal Transduction Research·Yuhong DuHaian Fu
Aug 17, 2010·Seminars in Oncology·Norleena P GullettOmer Kucuk
Jun 3, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laura BreenMartin Clynes
Oct 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Nabil F SabaFadlo R Khuri
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Hussein A N Al-WadeiHildegard M Schuller
Aug 23, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nico van Zandwijk
Aug 16, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Thiery-VuilleminJ C Soria
Apr 29, 2015·Cancer Letters·Abedul HaqueA R M Ruhul Amin
Dec 6, 2007·Journal of Korean Medical Science·Eun Jung ChoiYeul Hong Kim
Oct 28, 2014·PloS One·Xuan QiuYiyu Zou
Sep 10, 2016·PloS One·Hani LeeWoo-Young Kim
Jun 21, 2005·Nature Reviews. Cancer·Shoshana KleinAlexander Levitzki
Jun 11, 2005·Molecular Pharmacology·Ling-Zhi LiuBing-Hua Jiang
Mar 23, 2011·Virchows Archiv : an International Journal of Pathology·Vítor SousaLina Carvalho
Mar 24, 2016·Cancer Prevention Research·Humam KadaraAvrum E Spira
Mar 10, 2012·Cancer Prevention Research·Qi ZhangMing You
Feb 23, 2007·Molecular Cancer Research : MCR·Michalis V KaramouzisAthanasios G Papavassiliou