Molecularly targeted approaches to the chemoprevention of lung cancer

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Fadlo R Khuri, Victor Cohen

Abstract

Large, randomized trials have been conducted in the primary prevention of lung cancer using micronutrients or derivative agents for which epidemiological data suggested a potential role in lung cancer prevention. The disappointing primary prevention trials of beta-carotene, alpha-tocopherol, and retinyl palmitate have led to the development of a more compact, biomarker-driven series of translational trials of lung cancer prevention that target reversal of premalignancy as the primary end point. Serial trials of 13-cis-retinoic acid (isotretinoin) and other retinoids have failed to show a difference in reversal of premalignancy in active smokers or in second primary tumor prevention. However, a trial of 9-cis-retinoic acid, a pan retinoid/rexinoid agonist, showed up-regulation of retinoic acid receptor beta (RAR-beta), a potentially important intermediate marker of response in lung cancer premalignancy. Other planned or ongoing trials currently target important molecular markers of lung carcinogenesis and progression including cyclooxygenase-2, the ras-signaling pathway through farnesyl transferase inhibitors, and the tyrosine kinase/epidermal growth factor receptor pathway (gefitinib, erlotinib). Early results of bioadjuvant tr...Continue Reading

References

Sep 20, 1990·The New England Journal of Medicine·W K HongL J Peters
Dec 11, 1986·The New England Journal of Medicine·W K HongC Vaughan
Dec 1, 1995·The American Journal of Clinical Nutrition·J W McLartyS D Greenberg
Apr 14, 1994·The New England Journal of Medicine·UNKNOWN Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
May 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S LeeH A Fritsche
Jul 1, 1993·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·U PastorinoM Valente
May 2, 1996·The New England Journal of Medicine·G S OmennS Hammar
Jun 18, 1997·Journal of the National Cancer Institute·L MaoW K Hong
Oct 6, 1997·Journal of the National Cancer Institute·I I WistubaA F Gazdar
Aug 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F R KhuriX C Xu
Jan 29, 2003·Cancer Metastasis Reviews·Victor Cohen, Fadlo R Khuri
Feb 6, 2003·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Aug 10, 1961·The New England Journal of Medicine·O AUERBACHL GARFINKEL

❮ Previous
Next ❯

Citations

Nov 12, 2003·Clinical Lung Cancer·Angelia D Gibson
Nov 1, 2007·Journal of the National Cancer Institute·Walter N HittelmanJ Jack Lee
May 6, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A R M Ruhul AminDong M Shin
Aug 17, 2010·Seminars in Oncology·Norleena P GullettOmer Kucuk
Jun 3, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Laura BreenMartin Clynes
Oct 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Nabil F SabaFadlo R Khuri
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Hussein A N Al-WadeiHildegard M Schuller
Aug 23, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nico van Zandwijk
Aug 16, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Thiery-VuilleminJ C Soria
Dec 6, 2007·Journal of Korean Medical Science·Eun Jung ChoiYeul Hong Kim
Jun 21, 2005·Nature Reviews. Cancer·Shoshana KleinAlexander Levitzki
Mar 24, 2016·Cancer Prevention Research·Humam KadaraAvrum E Spira
Mar 10, 2012·Cancer Prevention Research·Qi ZhangMing You
Feb 23, 2007·Molecular Cancer Research : MCR·Michalis V KaramouzisAthanasios G Papavassiliou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Fred R Hirsch, Scott M Lippman
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Gary J KelloffAACR Task Force on Cancer Prevention
Expert Review of Anticancer Therapy
Lori J WirthMarshall R Posner
© 2022 Meta ULC. All rights reserved