Molecularly targeted therapies in adult soft tissue sarcomas: present approach and future directions

Expert Opinion on Therapeutic Targets
Olivia Aranha, Mark Agulnik

Abstract

Sarcomas are rare neoplasms. Given the overwhelming chemotherapy resistance of the disease, patients with progressive and metastatic soft tissue sarcomas are ideal candidates for trials of investigational new drugs. The authors review the molecular mechanisms underlying soft tissue sarcomas and discuss molecularly targeted therapies developed to improve the poor outcome of these uncommon tumors. A Medline and American Society of Clinical Oncology abstract search was conducted using the keyword 'soft tissue sarcoma'. Articles and abstracts were reviewed and eligible for inclusion if they used targeted therapies for the treatment of patients with soft tissue sarcomas. Phase II clinical trials for patients with soft tissue sarcomas using novel targets and present recognized targets are ongoing and planned.

References

Mar 1, 1989·Controlled Clinical Trials·R Simon
Jan 1, 1972·Journal of Surgical Oncology·J G JohnsonA L Watne
Jun 1, 1995·Human Pathology·S Pierce
Jul 1, 1993·Journal of Clinical Pathology·P KingA J Malcolm
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P W PistersM F Brennan
Jan 15, 1998·The New England Journal of Medicine·A KawaiM Ladanyi
Sep 28, 1998·International Archives of Occupational and Environmental Health·W Rhomberg
Jan 5, 2000·The Journal of Clinical Investigation·J B Gibbs
Dec 7, 2000·Genes, Chromosomes & Cancer·N R dos SantosA G van Kessel
Feb 7, 2001·Journal of the National Cancer Institute·M Hidalgo, S G Eckhardt
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mary CianfroccaBruce J Dezube
Aug 16, 2002·The New England Journal of Medicine·George D DemetriHeikki Joensuu
Jan 7, 2003·Hematology/oncology Clinics of North America·Janet E Dancey
Jan 11, 2003·Science·Michael C HeinrichJonathan A Fletcher
Apr 8, 2003·Current Medicinal Chemistry. Anti-cancer Agents·S ShinkarukG Déléris
Jul 9, 2003·The Journal of Biological Chemistry·Josiane SancéauBrigitte Bauvois
Sep 10, 2003·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Giovanni BarillariBarbara Ensoli
Dec 6, 2003·Oncology·Florence Duffaud, Jean-Yves Blay
Dec 24, 2003·The Cancer Journal·Diane D Davey
Jan 10, 2004·Clinical & Experimental Metastasis·Lesley J MurrayNancy K Pryer
Jan 31, 2004·Current Oncology Reports·Nithya Ramnath, Patrick J Creaven
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·Y M KirovaJ P Le Bourgeois
May 18, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jerzy LasotaMarkku Miettinen
Jun 30, 2004·The American Journal of Surgical Pathology·Fabiola MedeirosChristopher D M Fletcher
Jul 28, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S S YoonS Singer
Aug 26, 2004·Advances in Cancer Research·Brian J Druker
Nov 2, 2004·Nature Reviews. Cancer·Paolo MoniniBarbara Ensoli
Dec 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel J Hicklin, Lee M Ellis
Apr 19, 2005·Expert Opinion on Investigational Drugs·Janet E Dancey
Jun 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher L CorlessMichael C Heinrich
Aug 19, 2005·The New England Journal of Medicine·Matthew A ClarkJ Meirion Thomas
Sep 15, 2005·Head & Neck·Randall J OlsenStefano R Tarantolo
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David R D'AdamoRobert G Maki

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Citations

Dec 5, 2009·The Journal of Veterinary Medical Science·Hye-Jung YEOMSeung Young HWANG

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