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Molecule--receptor specificity

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Nov 6, 1975

William G RichardsC Robin Ganellin

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Abstract

The specificity of binding between small molecules and macromolecular receptors may be studied by comparing theoretically calculated conformational potential energy surfaces of a series of chemically similar molecules which have a range of receptor binding energies and biological activi...read more

Mentioned in this Paper

Small Molecule
Thermodynamics
Chemicals
Phenols
Receptors, Adrenergic, beta-1
Receptors, Drug
Metazoa
Ceplene
Structure-Activity Relationship
Solid state
Paper Details
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  • Molecule--receptor specificity

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

    Nov 6, 1975

    William G RichardsC Robin Ganellin

    PMID: 1819

    DOI: 10.1098/rstb.1975.0071

    Abstract

    The specificity of binding between small molecules and macromolecular receptors may be studied by comparing theoretically calculated conformational potential energy surfaces of a series of chemically similar molecules which have a range of receptor binding energies and biological activi...read more

    Mentioned in this Paper

    Small Molecule
    Thermodynamics
    Chemicals
    Phenols
    Receptors, Adrenergic, beta-1
    Paper Details
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