Molecules derived from tRNA and snoRNA: Entering the degradome pool

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Witold Światowy, Paweł P Jagodzińśki

Abstract

Molecules built of RNA have been the subjects of numerous studies, which have made known new functions and structures that these molecules can create. In recent years, thanks to next-generation sequencing, it is possible to observe very small RNAs and the number of newly discovered RNA molecules is rapidly increasing. Among other small oligonucleotides, structures derived from tRNA and snoRNA molecules have been observed, and these molecules were determined to not be precursors of known RNA molecules. These structures have attracted the attention of researchers because the level of accumulation of tRNA or snoRNA fragments was relatively high. Additionally, other parts of the parent molecules were absent. Derivatives of well-known RNA molecules also have functions that are different from their parent molecules. They are mainly involved in regulating the expression of genetic information in a similar way to miRNA. In addition, some of the miRNAs that have been described are derivatives of tRNA or snoRNA. Most of the research on these newly discovered molecules is based on their detection and on the study of the macro effects that they exert, in the absence of a description of the molecular mechanism by which they arise and work.

References

May 29, 2004·FEBS Letters·Céline Morey, Philip Avner
May 18, 2005·Trends in Biochemical Sciences·Ronald C ConawayJoan W Conaway
Nov 8, 2005·The Journal of Biological Chemistry·Suzanne R Lee, Kathleen Collins
Nov 21, 2007·Cell·Meenakshi K Doma, Roy Parker
Nov 26, 2008·Molecular Cell·Christine EnderGunter Meister
Dec 2, 2008·PLoS Pathogens·Ashesh A Saraiya, Ching C Wang
Feb 26, 2009·Cell·Jonathan Houseley, David Tollervey
Apr 1, 2009·The Journal of Cell Biology·Debrah M Thompson, Roy Parker
May 29, 2009·RNA·Ryan J TaftJohn S Mattick
Aug 15, 2009·PLoS Pathogens·Roland HutzingerAlexander Hüttenhofer
Sep 19, 2009·PLoS Computational Biology·Michelle S ScottGeoffrey J Barton
Oct 9, 2009·Journal of Virology·Zhihua LiBino John
Nov 26, 2009·Genes & Development·Yong Sun LeeAnindya Dutta
Apr 21, 2010·Plant Signaling & Behavior·Li-Ching HsiehTzyy-Jen Chiou
Aug 4, 2010·Genes & Development·Matthias SchaeferFrank Lyko
Sep 3, 2010·Genes & Development·Eric M Phizicky, Anita K Hopper
Sep 18, 2010·Nucleic Acids Research·Markus BrameierJens Gruber
Jun 10, 2011·Nucleic Acids Research·Paulina JackowiakMarek Figlerowicz
Aug 23, 2011·Molecular Cell·Pavel IvanovPaul Anderson
Oct 7, 2011·Wiley Interdisciplinary Reviews. RNA·Andrew Sobala, Gyorgy Hutvagner
Apr 24, 2012·Leukemia·W ValleronP Brousset
Jul 13, 2012·Genetics·Roy Parker
Aug 24, 2012·Genes·Mihaela Pertea
Nov 28, 2012·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Marina Falaleeva, Stefan Stamm
Jan 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Roy L MauteRiccardo Dalla-Favera
Jan 18, 2013·Archaea : an International Microbiological Journal·Jennifer GebetsbergerNorbert Polacek
Apr 3, 2013·Biochimica Et Biophysica Acta·Cecília Maria ArraianoBertrand Séraphin
Apr 16, 2013·Biochimica Et Biophysica Acta·Georg Stoecklin, Oliver Mühlemann
Dec 20, 2013·RNA Biology·Jennifer Gebetsberger, Norbert Polacek
Apr 1, 2014·Cell·Thomas R Cech, Joan A Steitz
Apr 24, 2014·RNA Biology·Julia BabskiJörg Soppa
Sep 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·In Hae ParkJoo-Hang Kim
Sep 10, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Vera SunAltaf A Dar
Apr 28, 2017·Cancer Research·Bingqing HuangRongxin Zhang

❮ Previous
Next ❯

Citations

Jan 15, 2020·Blood Cancer Journal·Gurvinder KaurRitu Gupta
May 10, 2020·Virology Journal·Barbara Małgorzata KalenikAgnieszka Sirko
May 20, 2020·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Rafal MorgaJoanna Pera
Nov 17, 2020·Frontiers in Genetics·Anahi Molla-HermanJean-René Huynh
May 4, 2021·Frontiers in Molecular Biosciences·Natalia MarkelovaOlga Ozoline

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.