Molybdenum metabolism in the alga Chlamydomonas stands at the crossroad of those in Arabidopsis and humans

Metallomics : Integrated Biometal Science
Angel LlamasAurora Galván

Abstract

Molybdenum (Mo) is a very scarce element whose function is fundamental in living beings within the active site of Mo-oxidoreductases, playing key roles in the metabolism of N, S, purines, hormone biosynthesis, transformation of drugs and xenobiotics, etc. In eukaryotes, each step from Mo acquisition until its incorporation into a biologically active molybdenum cofactor (Moco) together with the assembly of this Moco in Mo-enzymes is almost understood. The deficiency in function of a particular molybdoenzyme can be critical for the survival of the organism dependent on the pathway involved. However, incapacity in forming a functional Moco has a pleiotropic effect in the different processes involving this cofactor. A detailed overview of Mo metabolism: (a) specific transporters for molybdate, (b) the universal biosynthesis pathway for Moco from GTP, (c) Moco-carrier and Moco-binding proteins for Moco transfer and (d) Mo-enzymes, is analyzed in light of recent findings and three systems are compared, the unicellular microalga Chlamydomonas, the plant Arabidopsis and humans.

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Citations

Jun 27, 2013·Metallomics : Integrated Biometal Science·Manuel Tejada-JiménezAngel Llamas
Oct 14, 2016·The New Phytologist·Gianpiero ViganiIrene Murgia
Mar 25, 2017·International Journal of Molecular Sciences·Alejandro Chamizo-AmpudiaAngel Llamas
May 13, 2017·BioFactors·Angel LlamasEmilio Fernández
Jul 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yan Zhang, Junge Zheng
Oct 22, 2020·Bioscience Reports·Thomas W HercherTobias Kruse

Related Concepts

Molybdenum cofactor
Molybdate, (99)Mo-labeled
Chlamydomonas
Coenzymes
Metalloproteins
Molybdenum
Phylogeny
Pteridinones
Arabidopsis thaliana <plant>
Homologous Sequences, Amino Acid

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