Mometasone/formoterol inhalation aerosol: in asthma uncontrolled on medium- or high-dose inhaled corticosteroids.

Drugs
James E Frampton

Abstract

The corticosteroid mometasone and the long-acting β(2)-selective adrenoreceptor agonist formoterol have been combined in a single pressurized metered-dose inhaler for use in patients aged ≥12 years with asthma. In a 26-week well designed trial in patients with persistent asthma uncontrolled on medium-dose inhaled corticosteroids (ICS), mometasone/formoterol 200 μg/10 μg twice daily (bid) was more effective than placebo or the same nominal dosage of formoterol alone in reducing the incidence of asthma deteriorations, as well as in improving lung function, asthma control, asthma symptoms and asthma-related quality-of-life outcomes. The combination was also more effective than the same nominal dosage of mometasone alone in improving lung function and asthma control. Similarly, in a 12-week well designed trial in patients with persistent asthma uncontrolled on high-dose ICS, mometasone/formoterol 400 μg/10 μg bid was more effective than the same nominal dosage of mometasone alone in improving lung function, asthma control and asthma symptoms. Treatment with a lower dosage of the combination (200 μg/10 μg bid) yielded similar results and, moreover, significantly reduced the incidence of asthma deteriorations compared with mometasone...Continue Reading

References

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Jul 1, 2011·The New England Journal of Medicine·Badrul A ChowdhuryMark S Levenson

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Citations

Nov 19, 2013·Pharmaceutical Patent Analyst·Sukhbir K Shahid
Aug 25, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andriy Kuzmov, Tamara Minko
Jan 23, 2016·Expert Opinion on Pharmacotherapy·Hiroshi Chantaphakul, Kiat Ruxrungtham
Feb 1, 2013·Expert Opinion on Pharmacotherapy·Christian Grabow WestergaardVibeke Backer
Oct 15, 2013·Advanced Drug Delivery Reviews·Tamara MinkoVitaly Pozharov

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