Momordica charantia (Bitter Gourd) peel, pulp, seed and whole fruit extract inhibits mouse skin papillomagenesis

Toxicology Letters
A SinghR Bamezai

Abstract

The present study was designed to elucidate the inhibitory potential of Momordica charantia (Bitter Gourd) peel, pulp, seed and whole fruit extract on mouse skin papillomagensis with the modulatory influence of biotransformation system enzymes. Topical application of Momordica whole fruit extract (100 microl/animal per day) during the peri-initiation stage (1 week before and 2 weeks after initiation) by 7,12-dimethylbenz[a]anthracene (DMBA) and/or during the tumor promotion stage reduced the (i) tumor burden to 4.26, 3.72 and 3.11 (positive control value: 5.42); (ii) cumulative number of papillomas to 81, 67 and 53 (positive control value: 103); and (iii) percent incidence of mice bearing papillomas to 100, 94 and 94, respectively (positive control value: 100). In a comparison of the anticarcinogenic efficacy of Momordica peel, pulp, seed and whole fruit extract (100 microl/animal per day), after topical treatment during the peri-initiation and during the tumor promotion stage, revealed the modulation of the (i) tumor burden (tumors/mouse) to 3.06, 3.61, 3.17 and 3.11; (ii) cumulative number of papillomas to 49, 65, 54 and 53; and (iii) percent incidence of mice bearing papillomas to 84, 100, 94 and 94, respectively. Significan...Continue Reading

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Citations

Jul 13, 2004·Cancer Chemotherapy and Pharmacology·Pornngarm LimtrakulKomsak Pintha
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A SinghR Bamezai
Mar 7, 2014·Pharmacognosy Reviews·Nahida Tabassum, Mariya Hamdani
Jan 20, 2004·Bioscience, Biotechnology, and Biochemistry·Mariko ManabeOsamu Okinaka
Jun 9, 2004·Journal of Ethnopharmacology·J K Grover, S P Yadav
Jul 21, 2012·The Journal of Dermatological Treatment·Ahmet PişkinMurat Hökelek
Jun 9, 2005·The Journal of Veterinary Medical Science·Kazunori IkeSoichi Imai
Feb 13, 2015·International Journal of Oncology·Ranganatha R SomasagaraRajesh Agarwal
Jul 28, 2016·Seminars in Cancer Biology·Komal RainaRajesh Agarwal
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Nov 29, 2017·International Journal of Molecular Sciences·Shuo JiaJianhua Xie
Jul 20, 2019·Metabolomics : Official Journal of the Metabolomic Society·Shuaizhen ZhouJean-Luc Wolfender
May 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Nurul 'Ain Abu BakarYoke Keong Yong
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Dec 24, 2020·Current Pharmaceutical Design·Shaik I KhalivullaKokkanti Mallikarjuna

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