Momordica charantia Inhibits Inflammatory Responses in Murine Macrophages via Suppression of TAK1

The American Journal of Chinese Medicine
Woo Seok YangJae Youl Cho

Abstract

Momordica charantia known as bitter melon is a representative medicinal plant reported to exhibit numerous pharmacological activities such as antibacterial, antidiabetic, anti-inflammatory, anti-oxidant, antitumor, and hypoglycemic actions. Although this plant has high ethnopharmacological value for treating inflammatory diseases, the molecular mechanisms by which it inhibits the inflammatory response are not fully understood. In this study, we aim to identify the anti-inflammatory mechanism of this plant. To this end, we studied the effects of its methanol extract (Mc-ME) on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Specifically, we evaluated nitric oxide (NO) production, mRNA expression of inflammatory genes, luciferase reporter gene activity, and putative molecular targets. Mc-ME blocked NO production in a dose-dependent manner in RAW264.7 cells; importantly, no cytotoxicity was observed. Moreover, the mRNA expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 were decreased by Mc-ME treatment in a dose-dependent manner. Luciferase assays and nuclear lysate immunoblotting analyses strongly indicated that Mc-ME decreases the levels of p65 [a nuclear factor (NF)-[Formula: see text]B subun...Continue Reading

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Citations

Oct 16, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kon Kuk ShinJae Youl Cho
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shi Yan LeeKian-Kai Cheng
May 30, 2019·Frontiers in Pharmacology·Massimo BortolottiLetizia Polito
Nov 17, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Kong Yen LiewChau Ling Tham
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chaoran SongJae Youl Cho
Aug 26, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Wusa MakenaNathan Isaac Dibal

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