Monascin inhibits IL-1β induced catabolism in mouse chondrocytes and ameliorates murine osteoarthritis

Food & Function
Gang ZhengXiao-Lei Zhang

Abstract

Osteoarthritis (OA) is an age-related degenerative disease and is the fourth major cause of disability, but there are no effective therapies because of its complex pathology and the side effects of the drugs. Previous research demonstrated that inflammation and ECM degradation play major roles in OA development. Monascin is an azaphilonoid pigment extracted from Monascus-fermented rice with a potential anti-inflammatory effect reported in various preclinical studies. In the present study, we investigated the protectiveness of monascin on interleukin (IL)-1β-induced mouse chondrocytes and surgical destabilization of the medial meniscus mouse (DMM) OA models. In vitro, monascin treatment inhibited the IL-1β-induced expression of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6). In addition, the IL-1β-stimulated matrix metalloproteinase-13 (MMP-13) and thrombospondin motifs 5 (ADAMTS-5) upregulation and type two collagen and aggrecan degradation were reversed by monascin. Mechanistically, we revealed that monascin suppressed nuclear factor kappa B (NF-κB) signalling by activating the nuclear factor (erythroid-...Continue Reading

References

Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Nov 16, 2001·Current Rheumatology Reports·S B AbramsonR Clancy
Jun 4, 2004·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ashok KumarBharat B Aggarwal
Oct 14, 2004·Clinical Orthopaedics and Related Research·Steven R Goldring, Mary B Goldring
Apr 6, 2006·The Journal of Clinical Investigation·Rajesh K ThimmulappaShyam Biswal
Nov 14, 2006·Biochemical and Biophysical Research Communications·Rajesh K ThimmulappaShyam Biswal
Oct 13, 2009·Molecular Cell·Dung-Fang LeeMien-Chie Hung
Mar 3, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei-Hsuan HsuTzu-Ming Pan
Mar 27, 2012·The Journal of Nutritional Biochemistry·Ilaria BellezzaAlba Minelli
Mar 6, 2013·Journal of Agricultural and Food Chemistry·Li-Chuan HsuTzu-Ming Pan
Nov 28, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wei-Hsuan HsuTzu-Ming Pan
Dec 7, 2013·Clinical Orthopaedics and Related Research·R Krishna ChagantiLisa A Mandl
Mar 22, 2014·Biochemical Society Transactions·Usman AhmedNaila Rabbani
Apr 23, 2014·Food & Function·Wei-Hsuan Hsu, Tzu-Ming Pan
Dec 20, 2014·Journal of Agricultural and Food Chemistry·Yu-Ying ChangTzu-Ming Pan
Mar 10, 2015·Lancet·S Glyn-JonesA J Carr
Sep 27, 2015·Arthritis Research & Therapy·Dawei CaiWangsen Cao
Dec 29, 2015·Osteoarthritis and Cartilage·N H Varady, A J Grodzinsky
Dec 3, 2016·Current Opinion in Rheumatology·Margaret Man-Ger SunMichael A Pest
Jan 4, 2017·Mechanisms of Ageing and Development·Yu-Sheng LiWei Luo
Jan 20, 2017·Osteoarthritis and Cartilage·N E LaneB L Wise
Jul 1, 2017·Annals of the New York Academy of Sciences·Andrey S MarchevMilen I Georgiev

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Citations

Oct 27, 2020·Frontiers in Cell and Developmental Biology·He ZhangLunhao Bai
May 4, 2020·International Immunopharmacology·Zijian YanXiaoyun Pan
Feb 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ximiao ChenChaoyong Bei
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junliang FeiLiming Wang
Apr 4, 2021·Antioxidants·Yohei SanadaShigeru Miyaki
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yongsheng WangGuangjie Yang
Jun 7, 2021·European Journal of Pharmacology·Xiaojian HuangHongbo You
Aug 13, 2021·Journal of Cellular and Molecular Medicine·Xiaolang LuYang Yang

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Methods Mentioned

BETA
X-ray
ELISA
PCR
protein assay
electrophoresis
transfection
nuclear translocation

Software Mentioned

Image Lab
Image J
SPSS
BLAST
Primer

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