Monitoring Anti-Pythium insidiosum IgG Antibodies and (1→3)-β-d-Glucan in Vascular Pythiosis

Journal of Clinical Microbiology
Navaporn WorasilchaiAriya Chindamporn

Abstract

Despite aggressive treatment, vascular pythiosis has a mortality rate of 40%. This is due to delays in diagnosis and a lack of effective monitoring tools. To overcome this drawback, serum beta-d-glucan (BG) and P. insidiosum-specific antibody (Pi-Ab) were examined as potential monitoring markers in vascular pythiosis. A prospective cohort study of vascular pythiosis patients was carried out from January 2010 to July 2016. Clinical information and blood samples were collected and evaluated by the BG and Pi-Ab assays. Linear mixed-effect models were used to compare BG and Pi-Ab levels. The in vitro susceptibility test was performed with all P. insidiosum isolates from culture-positive cases. A total of 50 patients were enrolled: 45 survived and 5 died during follow-up. The survivors had a significantly shorter time to medical care (P < 0.0001) and a significantly shorter waiting time to the first surgery (P < 0.0001). There were no differences in BG levels among the groups at diagnosis (P = 0.33); however, BG levels among survivors were significantly lower than those of the deceased group at 0.5 months (P < 0.0001) and became undetectable after 3 months. Survivors were able to maintain an enzyme-linked immunosorbent assay (ELISA)...Continue Reading

References

Jun 1, 1993·Journal of Cutaneous Pathology·J A TriscottE Cabana
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·D Murdoch, D Parr
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J L ShenepM G Rinaldi
Dec 30, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A ThitithanyanontL Ajello
Apr 17, 2001·The British Journal of Ophthalmology·P R BadenochG Wagels
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Theerapong KrajaejunRoongnapa Pracharktam
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Zekaver OdabasiLuis Ostrosky-Zeichner
May 14, 2005·Emerging Infectious Diseases·Sandra de Moraes Gimenes BoscoSilvio Alencar Marques
Dec 8, 2005·Journal of Clinical Microbiology·Jerry W PickeringGail L Woods
Jun 30, 2006·The New England Journal of Medicine·Monique A S H Mennink-KerstenPaul E Verweij
Aug 4, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Theerapong KrajaejunShawarash Somkaew
Aug 23, 2008·Medical Mycology·Francisco M Marty, Sophia Koo
Nov 3, 2009·Clinical & Experimental Ophthalmology·Paul R BadenochDouglas J Coster
Aug 31, 2010·Veterinary Microbiology·Wim GaastraLeonel Mendoza
Jan 22, 2011·Eye & Contact Lens·Tasha Y TanhehcoKathryn A Colby
Mar 31, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J Held, D Wagner
Mar 31, 2012·Journal of Clinical Microbiology·Charles R SimsLuis Ostrosky-Zeichner
May 1, 2013·Seminars in Ophthalmology·Irina S BarequetMordechai Rosner
Aug 20, 2015·The International Journal of Lower Extremity Wounds·Termpong ReanpangKittipan Rerkasem
Feb 26, 2016·Archives of Pathology & Laboratory Medicine·Tuan Tran, Stacy G Beal
Oct 21, 2016·Journal of Vascular Surgery·Nuttawut SermsathanasawadiPramook Mutirangura

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Citations

Feb 6, 2020·Antimicrobial Agents and Chemotherapy·Navaporn WorasilchaiNitipong Permpalung
Dec 18, 2019·Mycopathologia·Nitipong PermpalungAriya Chindamporn
Mar 3, 2020·PeerJ·Maria Nina ChitasombatTheerapong Krajaejun

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