Monitoring blood glucose changes in cutaneous tissue by temperature-modulated localized reflectance measurements

Clinical Chemistry
Shu-Jen YehOmar S Khalil

Abstract

Most proposed noninvasive methods for glucose measurements do not consider the physiologic response of the body to changes in glucose concentration. Rather than consider the body as an inert matrix for the purpose of glucose measurement, we exploited the possibility that noninvasive measurements of glucose can be approached by investigating their effects on the skin's thermo-optical response. Glucose concentrations in humans were correlated with temperature-modulated localized reflectance signals at wavelengths between 590 and 935 nm, which do not correspond to any near-infrared glucose absorption wavelengths. Optical signal was collected while skin temperature was modulated between 22 and 38 degrees C over 2 h to generate a periodic set of cutaneous vasoconstricting and vasodilating events, as well as a periodic change in skin light scattering. The method was tested in a series of modified meal tolerance tests involving carbohydrate-rich meals and no-meal or high-protein/no-carbohydrate meals. The optical data correlated with glucose values. Changes in glucose concentrations resulting from a carbohydrate-rich meal were predicted with a model based on a carbohydrate-meal calibration run. For diabetic individuals, glucose concen...Continue Reading

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Citations

Oct 19, 2007·Medical Engineering & Physics·Carlos Eduardo Ferrante do Amaral, Benhard Wolf
Dec 5, 2006·Diabetes Research and Clinical Practice·Andrea TuraGiovanni Pacini
Jun 6, 2013·Analytical Chemistry·Magnus FalkSergey Shleev
Apr 14, 2007·Analytical and Bioanalytical Chemistry·Venkata Radhakrishna Kondepati, H Michael Heise
Mar 2, 2005·Diabetes Technology & Therapeutics·Anke SiegM Begoña Delgado-Charro
Sep 22, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Francisco J Ascaso, Valentín Huerva

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