Monitoring Crohn's disease activity: endoscopy, fecal markers and computed tomography enterography

Therapeutic Advances in Gastroenterology
Susana LopesFernando Magro

Abstract

The treatment goal of Crohn's disease (CD) has moved towards achieving mucosal healing, resolution of transmural inflammation, and normalization of biomarkers. The purpose of this study was to evaluate how well computed tomography enterography (CTE) and fecal calprotectin (FC) correlated with endoscopic activity in newly diagnosed patients with CD and after 1 year of therapy. Consecutive patients with newly diagnosed CD were evaluated by endoscopy, CTE, and FC at diagnosis and 12 months after beginning immunosuppression. Endoscopic severity was assessed using the Simplified Endoscopic Score for Crohn's Disease (SES-CD). Biomarkers, clinical indexes, and FC were recorded on the day of ileocolonoscopy at diagnosis and 1 year after diagnosis. We adapted a CTE score for disease activity based on radiological signs of inflammation (i.e. mural thickness, mural hyperenhancement, mesenteric fat proliferation, mesenteric fat densification, comb sign, presence of strictures, fistulas, abscesses, ascites, and lymphadenopathy). Correlations between endoscopy, CTE, and FC were assessed using Spearman's rank correlation. A total of 29 patients (48% women; median age 30 (24.5-35.5) years) were included in this prospective cohort. CTE findings...Continue Reading

References

May 24, 2000·Abdominal Imaging·F MaccioniP Rossi
Jul 20, 2000·Investigative Radiology·K SchunkR Wanitschke
Sep 29, 2007·The American Journal of Gastroenterology·Michael V ChioreanCynthia S Johnson
May 22, 2008·AJR. American Journal of Roentgenology·Amy K HaraJonathan A Leighton
Jun 23, 2009·AJR. American Journal of Roentgenology·Hassan A SiddikiJayawant N Mandrekar
Aug 5, 2009·Inflammatory Bowel Diseases·Geert R D'HaensUNKNOWN IOIBD Membership
Dec 3, 2010·Journal of Crohn's & Colitis·A DignassUNKNOWN European Crohn's and Colitis Organisation (ECCO)
May 31, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·David H BruiningJoel G Fletcher
Sep 24, 2011·Journal of Crohn's & Colitis·Laurent Peyrin-BirouletUNKNOWN Scientific Committee of the European Crohn's and Colitis Organization
Feb 22, 2012·Inflammatory Bowel Diseases·Geert D'HaensPaul Rutgeerts
Apr 17, 2012·Gastroenterology Clinics of North America·Bincy P Abraham, Sunanda Kane
May 4, 2012·The British Journal of Radiology·R IlangovanS A Taylor
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Nov 5, 2013·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN European Crohn's and Colitis Organisation
May 20, 2015·Journal of Clinical Gastroenterology·Cong DaiMing-Jun Sun
Aug 26, 2015·The American Journal of Gastroenterology·L Peyrin-BirouletJ-F Colombel
Aug 3, 2016·Inflammatory Bowel Diseases·Susana LopesFernando Magro
Oct 30, 2016·Journal of Visceral Surgery·M BarralP Soyer

❮ Previous
Next ❯

Citations

Jun 6, 2020·Diagnostics·Małgorzata Krzystek-KorpackaKatarzyna Neubauer
Feb 6, 2020·Journal of Crohn's & Colitis·Fernando Magro, Maria Manuela Estevinho
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Christopher MaBrian Gordon Feagan
May 6, 2021·Therapeutic Advances in Gastroenterology·Rune WilkensTorsten Kucharzik
Jun 3, 2021·Journal of Clinical Medicine·Mariusz A BromkeMałgorzata Krzystek-Korpacka
Oct 26, 2021·The Korean Journal of Internal Medicine·Hye Kyung HyunJae Hee Cheon

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

Statistical Package for Social Sciences ( SPSS
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.