Monitoring genotoxicity among gasoline station attendants and traffic enforcers in the City of Manila using the micronucleus assay with exfoliated epithelial cells.

Environmental Monitoring and Assessment
A V HallareP J B Acacio-Claro

Abstract

Some types of occupations involve high levels of exposure to potentially genotoxic gaseous and particulate substances from internal combustion engines used in motor vehicles. These occupational exposures may contribute to the development of many illnesses, usually through chromosomal change mechanisms that include strand breakage, deletions, sister chromatid exchange and non-disjunction. To determine the effect of occupational exposure in gasoline station attendants and traffic enforcers, the micronucleus test was used. Exfoliated oral mucosa cells from 18 gasoline station attendants, 18 traffic enforcers and 18 control subjects in the City of Manila were examined for micronucleated cell (MNC) frequency. Analysis of buccal cells showed that MNC frequencies in exposed individuals were significantly greater than in control subjects (p < or = 0.05). However, between gasoline station attendants and traffic enforcers, MNC frequencies of the two exposed groups exhibited no significant difference. No relation was also found between MNC frequency and any of the factors such as age, smoking habits, alcohol habits and working period. This was further confirmed in the multiple regression analysis which showed that only occupational exposu...Continue Reading

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Citations

May 11, 2011·International Journal of Environmental Research and Public Health·Alejandro Canales-AguirreRuth De Celis
Aug 29, 2014·International Journal of Environmental Research and Public Health·Alan da Silveira FleckClaudia Ramos Rhoden
Nov 6, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Xiao ZhangYuxin Zheng
Nov 7, 2016·Environmental Science and Pollution Research International·C Martínez-ValenzuelaR Longoria-Espinoza
Nov 11, 2016·Environmental Geochemistry and Health·Diana Paula Silva LinharesArmindo Dos Santos Rodrigues
Dec 2, 2009·Environmental and Molecular Mutagenesis·Virginia LopeNuria Aragonés
Oct 14, 2016·Environmental Science and Pollution Research International·Carmen Martinez-ValenzuelaMario Caba
Nov 10, 2012·Environmental Monitoring and Assessment·João Carlos Fraga da RosaValesca Veiga Cardoso
Mar 16, 2018·Environmental Monitoring and Assessment·Érica Prado DominguesBoscolli Barbosa Pereira
Jun 28, 2019·International Journal of Environmental Research and Public Health·Isabele C Costa-AmaralAriane L Larentis
Oct 30, 2016·European Journal of Medical Genetics·Darko GrujičićOlivera Milošević-Djordjević

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