PMID: 6970019Feb 1, 1981Paper

Monitoring heparin anticoagulation and its neutralization

The Annals of Thoracic Surgery
D R JobesJ J Ruffini

Abstract

Heparin anticoagulation and its neutralization were monitored by three different techniques: a manual protamine titration, an automated activated coagulation time, and an automated protamine titration. All three techniques provided satisfactory information. The decision of which to use must be based on other considerations such as available manpower and cost of equipment. The effect of using the automated protamine titration test on heparin and protamine requirements, and on blood loss measured intraoperatively after bypass and in overnight chest bottle drainage in two groups of comparable patients undergoing coronary artery bypass operation was studied. The heparin requirements were similar (24,420 +/- 584 units, control group; 23,550 +/- 849 units, treatment group), but the protamine requirements were markedly different (429 +/- 14.7 mg, control; 258 +/- 10.4 mg, treatment; p < 0.05). There was no statistical difference in intraoperative blood loss or overnight chest bottle drainage.

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References

Jan 1, 1978·Anesthesiology·N EllisonR W Colman
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Feb 1, 1974·The Annals of Thoracic Surgery·J D HillC H Mielke

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Citations

Dec 17, 2009·British Journal of Anaesthesia·L J Enriquez, L Shore-Lesserson
Oct 1, 1991·Journal of Cardiothoracic and Vascular Anesthesia·J BoldtG Hempelmann
Dec 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·D L ReichD M Thys
Sep 1, 1992·The Annals of Thoracic Surgery·F H KernP R Hickey
May 1, 1992·The Annals of Thoracic Surgery·F HorkayD R Walker
Jun 1, 1983·The Annals of Thoracic Surgery·W P FiserT J Vecchio
Jun 1, 1983·The Annals of Thoracic Surgery·A L PaucaA S Hudspeth
Sep 22, 2016·Best Practice & Research. Clinical Anaesthesiology·H LanderD FitzGerald
Jun 25, 2002·Asian Cardiovascular & Thoracic Annals·Peter Svenarud, Eivind Øvrum
Nov 15, 2013·Circulation·Therese M GigliaUNKNOWN American Heart Association Congenital Heart Defects Committee of the Council on Cardiovascular Disease in the Young, Council
Jan 1, 1987·Catheterization and Cardiovascular Diagnosis·G J DehmerJ M Schmitz
Jan 1, 1984·Scandinavian Journal of Thoracic and Cardiovascular Surgery·J NiinikoskiM V Inberg
Jan 1, 1992·Journal of Clinical Monitoring·D L ReichD M Thys
Jan 18, 2018·Chemical Reviews·Jooyeon ParkHyunjoon Kong

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