Monitoring hospital wastewaters for their probable genotoxicity

Journal of Water and Health
Asma BeltifaHedi Ben Mansour

Abstract

Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very...Continue Reading

References

Nov 1, 1993·Chemical Research in Toxicology·L J Marnett, P C Burcham
Dec 13, 2000·Mutation Research·G Krishna, M Hayashi
May 10, 2001·Mutation Research·R D Snyder, J W Green
Jul 24, 2002·Biology of Reproduction·Susan JoblingJ P Sumpter
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S S SmailiR J Youle
Jun 14, 2003·TheScientificWorldJournal·Luc Verschaeve
Aug 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Takahisa YanoRyozo Oishi
Feb 2, 2008·Environmental and Molecular Mutagenesis·Hifzur R SiddiqueDebapratim K Chowdhuri
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Karen P Phillips, Warren G Foster
Feb 3, 2009·Chemosphere·Klaus Kümmerer
Apr 1, 2009·Genetics and Molecular Biology·Adekunle A BakareHafeez B Jenmi
Jan 14, 2017·Environmental Monitoring and Assessment·Gulsum YilmazJochen Tuerk
Mar 6, 2018·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Takashi Azuma

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Citations

Jul 28, 2020·The American Journal of Bioethics : AJOB·Toby SchonfeldCynthia Geppert
May 14, 2020·Environmental Monitoring and Assessment·Angélica Oliveira FurtadoVeronica Elisa Pimenta Vicentini

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