Monitoring human immunodeficiency virus type 1-infected patients by ratio of antibodies to gp41 and p24.

Journal of Clinical Microbiology
G SchmidtD S Berns

Abstract

Antibody responses of 85 patients to human immunodeficiency virus type 1 antigens were quantitated by densitometric analysis of Western blot (immunoblot) assays. All patients had been classified into the following three clinical categories: asymptomatic (ASY), acquired immunodeficiency syndrome (AIDS)-related complex (ARC), or AIDS. Fifty of the patients were monitored for 6 to 29 months. The gp41/p24 antibody ratio was examined in three studies. In the first study, initial specimens from each patient were analyzed. The mean gp41/p24 antibody ratios were 1.5 (ASY), 3.2 (ARC), and 5.4 (AIDS). Of ASY patients, 79% had antibody ratios of less than 2.0. In contrast, 72% of patients with AIDS had ratios of greater than or equal to 2.0. In the second study, serially obtained specimens from ASY, ARC, and AIDS patients were analyzed. These patients were further grouped according to progression of their clinical condition. Of ASY patients whose clinical condition progressed to ARC, 80% consistently had ratios of greater than or equal to 2.0. Of ARC patients whose clinical condition progressed to AIDS, 71% consistently had ratios of greater than or equal to 2.0. Of AIDS patients who died during the study, 100% consistently had ratios of ...Continue Reading

References

Feb 1, 1988·AIDS Research and Human Retroviruses·A L DeVicoM G Sarngadharan
Jan 9, 1986·The New England Journal of Medicine·R R RedfieldE C Tramont
Jan 31, 1985·The New England Journal of Medicine·J SchüpbachR C Gallo
Apr 1, 1986·The Journal of Infectious Diseases·J E GroopmanS Landesman
Apr 1, 1987·The Journal of Infectious Diseases·L Z PanJ A Levy
Feb 1, 1984·Clinical Immunology and Immunopathology·B E KlosterT J Spira
Sep 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H WachterT J Spira
Aug 1, 1982·The American Journal of Medicine·R E StahlS Zolla-Pazner

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Citations

Nov 1, 1992·AIDS Research and Human Retroviruses·S HaistS Modrow
Mar 1, 1992·British Journal of Addiction·J F SamuelsR E Chaisson

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