Monitoring Hydrogenation Reactions using Benchtop 2D NMR with Extraordinary Sensitivity and Spectral Resolution

ChemistryOpen
Dariusz GołowiczTomasz Ratajczyk

Abstract

Low-field benchtop nuclear magnetic resonance (BT-NMR) spectrometers with Halbach magnets are being increasingly used in science and industry as cost-efficient tools for the monitoring of chemical reactions, including hydrogenation. However, their use of low-field magnets limits both resolution and sensitivity. In this paper, we show that it is possible to alleviate these two problems through the combination of parahydrogen-induced polarization (PHIP) and fast correlation spectroscopy with time-resolved non-uniform sampling (TR-NUS). PHIP can enhance NMR signals so that substrates are easily detectable on BT-NMR spectrometers. The interleaved acquisition of one- and two-dimensional spectra with TR-NUS provides unique insight into the consecutive moments of hydrogenation reactions, with a spectral resolution unachievable in a standard approach. We illustrate the potential of the technique with two examples: the hydrogenation of ethylphenyl propiolate and the hydrogenation of a mixture of two substrates - ethylphenyl propiolate and ethyl 2-butynoate.

References

Apr 25, 2006·Physical Chemistry Chemical Physics : PCCP·G BuntkowskyB Chaudret
Mar 4, 2008·Journal of the American Chemical Society·Victor A JaravineVladislav Yu Orekhov
Oct 15, 2008·Journal of Biomolecular NMR·Brian E Coggins, Pei Zhou
Mar 17, 2009·Journal of the American Chemical Society·Yoh MatsukiJudith Herzfeld
Apr 8, 2010·Journal of Biomolecular NMR·Jan Stanek, Wiktor Koźmiński
Nov 17, 2010·Chemical Communications : Chem Comm·Joel A TangAlexej Jerschow
Apr 8, 2011·Journal of the American Chemical Society·Michael J CowleyRyan E Mewis
May 4, 2011·Angewandte Chemie·Krzysztof Kazimierczuk, Vladislav Yu Orekhov
Nov 1, 2008·Concepts in Magnetic Resonance. Part A, Bridging Education and Research·Mehdi Mobli, Jeffrey C Hoch
Jun 8, 2011·Angewandte Chemie·Daniel J HollandDaniel Nietlispach
Feb 2, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Franz DalitzGisela Guthausen
Mar 1, 2012·Solid State Nuclear Magnetic Resonance·Tomasz RatajczykGerd Buntkowsky
Oct 30, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Richard A GreenGary G R Green
Jan 18, 2014·Journal of Biomolecular NMR·Maxim MayzelVladislav Y Orekhov
May 28, 2014·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Wolfgang BermelKrzysztof Kazimierczuk
Oct 3, 2014·Chemical Communications : Chem Comm·Yuting WuLynn F Gladden
Dec 17, 2014·Analytical Chemistry·Rupashree DassKrzysztof Kazimierczuk
Jan 3, 2015·Journal of Magnetic Resonance·I PrinaR H Acosta
Sep 19, 2015·Nature Communications·Susanna AholaVille-Veikko Telkki
Feb 22, 2016·Journal of Magnetic Resonance·Rupashree DassKrzysztof Kazimierczuk
Nov 12, 2016·Journal of Biomolecular NMR·Alexandra ShchukinaKrzysztof Kazimierczuk
Jan 10, 2017·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Danila A BarskiyEduard Y Chekmenev
Jun 24, 2017·Angewandte Chemie·Kirill V KovtunovBoyd M Goodson
Aug 5, 2017·Frontiers in Microbiology·Rupashree DassKrzysztof Kazimierczuk
Dec 13, 2017·Angewandte Chemie·Bernhard Blümich, Kawarpal Singh
Jan 10, 2018·Angewandte Chemie·Peter J Rayner, Simon B Duckett
May 24, 2018·Chemistry, an Asian Journal·Kirill V KovtunovIgor V Koptyug
Aug 18, 2018·Magnetic Resonance in Chemistry : MRC·Keunhong JeongSung Keon Namgoong
Sep 27, 2018·Magnetic Resonance in Chemistry : MRC·Mateusz UrbańczykKrzysztof Kazimierczuk

❮ Previous
Next ❯

Citations

Jan 29, 2020·Phytochemical Analysis : PCA·Teris André van Beek
Jan 18, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mihajlo NovakovicLucio Frydman
Oct 6, 2020·Magnetic Resonance in Chemistry : MRC·Dariusz GołowiczKrzysztof Kazimierczuk
Sep 7, 2020·Magnetic Resonance in Chemistry : MRC·Ellen SteimersDaniel J Holland
May 25, 2021·Journal of Magnetic Resonance·A BahtiD Suter
Jun 20, 2020·Analytical Chemistry·Mateusz UrbańczykVille-Veikko Telkki

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

mddNMR
TReNDS
TR
MATLAB
Magritek Spinsolve Expert
ALTADENA
NUS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry
Ernesto DanieliFederico Casanova
The Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Danila A BarskiyEduard Y Chekmenev
Magnetic Resonance in Chemistry : MRC
Keunhong JeongSung Keon Namgoong
Magnetic Resonance in Chemistry : MRC
Mateusz UrbańczykKrzysztof Kazimierczuk
Progress in Nuclear Magnetic Resonance Spectroscopy
Franz DalitzGisela Guthausen
© 2022 Meta ULC. All rights reserved