Monitoring hypercoagulability and hypofibrinolysis following acute venous Thromboembolism in children: application of the CloFAL assay in a prospective inception cohort study

Thrombosis Research
Christopher BombardierNeil A Goldenberg

Abstract

Although individual thrombophilia tests are frequently performed in children with venous thromboembolism (VTE), global assays provide the opportunity to fill the gap in knowledge regarding their net impact on overall coagulative (and in some cases fibrinolytic) function. We first evaluated analytic sensitivity of the Clot Formation and Lysis (CloFAL) global assay to hypercoagulability and alterations in fibrinolysis, and then characterized changes in plasma coagulative and fibrinolytic capacities over time in children with acute VTE. In plasma ex vivo and in vitro experiments, the CloFAL assay area-under-the-curve (AUC) was analytically sensitive to hypercoagulable states, and its modified fibrinolytic index (FI2) was sensitive to both hyper- and hypofibrinolytic conditions. Clinical data and plasma samples for assay were collected during follow-up of 50 children enrolled in a prospective inception cohort study of VTE from May 2006 to June 2010. Follow-up periods were designated as follows: acute (<1 month post-event), sub-acute (1-3 months), early chronic (3-12 months), and late chronic (>12 months). Since most children were sampled at fewer than three pre-defined follow-up periods, study population findings were grouped by ti...Continue Reading

References

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Citations

Feb 27, 2015·Thrombosis Research·Kevin DietrichLesley G Mitchell
May 21, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·L A GreeneD M DiMichele
Aug 28, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Maria FarmJovan P Antovic
Jan 29, 2020·Research and Practice in Thrombosis and Haemostasis·Anton IlichNigel S Key
May 21, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Lauren K Stewart, Jeffrey A Kline

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