Monitoring in vivo (re)modeling: a computational approach using 4D microCT data to quantify bone surface movements

Bone
Annette I BirkholdBettina M Willie

Abstract

Bone undergoes continual damage repair and structural adaptation to changing external loads with the aim of maintaining skeletal integrity throughout life. The ability to monitor bone (re)modeling would allow for a better understanding in how various pathologies and interventions affect bone turnover and subsequent bone strength. To date, however, current methods to monitor bone (re)modeling over time and in space are limited. We propose a novel method to visualize and quantify bone turnover, based on in vivo microCT imaging and a 4D computational approach. By in vivo tracking of spatially correlated formation and resorption sites over time it classifies bone restructuring into (re)modeling sequences, the spatially and temporally linked sequences of formation, resorption and quiescent periods on the bone surface. The microCT based method was validated using experimental data from an in vivo mouse tibial loading model and ex vivo data of the mouse tibia. In this application, the method allows the visualization of time-resolved cortical (re)modeling and the quantification of short-term and long-term modeling on the endocortical and periosteal surface at the mid-diaphysis of loaded and control mice tibiae. Both short-term and long...Continue Reading

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Citations

Mar 24, 2016·Scientific Reports·Annette I BirkholdBettina M Willie
Feb 3, 2015·Experimental Gerontology·Marta AidoBettina M Willie
Jun 24, 2017·Current Osteoporosis Reports·Patrik Christen, Ralph Müller
Mar 21, 2019·Journal of the Royal Society, Interface·Zihui LiDavide Ruffoni
Sep 12, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Russell P MainBettina M Willie
Aug 4, 2015·Current Rheumatology Reports·Alesha B Castillo, Philipp Leucht
Oct 24, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takeshi MatsumotoKentaro Uesugi
Jul 25, 2017·Biomechanics and Modeling in Mechanobiology·Ariane ScheurenRalph Müller
Dec 22, 2016·Calcified Tissue International·Annette I BirkholdBettina M Willie
Nov 30, 2019·Biomechanics and Modeling in Mechanobiology·Alexander F van TolRichard Weinkamer
Mar 18, 2020·Science Advances·Behzad JavaheriAndrew A Pitsillides
Dec 9, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alexander Franciscus van TolRichard Weinkamer
Dec 17, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keith ThompsonVincent A Stadelmann
Dec 10, 2020·Inflammation and Regeneration·Kunihiko HashimotoMasaru Ishii
Mar 30, 2021·JBMR Plus·Alessandra CarrieroSandra J Shefelbine

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