Monitoring influenza virus susceptibility to oseltamivir using a new rapid assay, iART

Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin
Larisa V GubarevaRoss Jacobson

Abstract

A new rapid assay for detecting oseltamivir resistance in influenza virus, iART, was used to test 149 clinical specimens. Results were obtained for 132, with iART indicating 41 as 'resistant'. For these, sequence analysis found known and suspected markers of oseltamivir resistance, while no such markers were detected for the remaining 91 samples. Viruses isolated from the 41 specimens showed reduced or highly reduced inhibition by neuraminidase inhibition assay. iART may facilitate broader antiviral resistance testing.

References

Nov 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Naoki KawaiSeizaburo Kashiwagi
Feb 9, 2012·Antiviral Therapy·Ha T NguyenLarisa V Gubareva
Dec 4, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·C I ThompsonM C Zambon
Mar 26, 2013·Antiviral Research·Mélanie SamsonGuy Boivin
Dec 23, 2014·Emerging Infectious Diseases·Margaret Okomo-AdhiamboUNKNOWN 2013–14 US Influenza Antiviral Working Group

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Citations

Oct 10, 2018·Current Opinion in Infectious Diseases·Nelson Lee, Aeron C Hurt
Jun 13, 2019·Influenza and Other Respiratory Viruses·Erin N HodgesLarisa V Gubareva

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Methods Mentioned

BETA
PCR

Software Mentioned

iART

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