Monitoring of cerebral oxygenation with near infrared spectroscopy and tissue oxygen partial pressure during cardiopulmonary resuscitation in pigs

European Journal of Anaesthesiology
Berthold BeinVolker Dörges

Abstract

The present study was designed to compare cerebral oxygenation measured with near infrared spectroscopy and local brain tissue oxygen partial pressure, respectively, in pigs during cardiopulmonary resuscitation. Since tissue overlying the brain may have an impact on near infrared spectroscopy readings, we tested whether optode placement on intact skin or on the skull yielded comparable results. Twelve healthy pigs were anaesthetized and subjected to continuous haemodynamic, near infrared spectroscopy and brain tissue oxygen partial pressure monitoring. After 4 min of untreated ventricular fibrillation, cardiopulmonary resuscitation was started and arginine vasopressin was administered repeatedly three times. Near infrared spectroscopy values recorded were both the tissue oxygenation index and the tissue haemoglobin index as well as relative changes of chromophores (haemoglobin and cytochrome oxidase). Four animals served as control and were measured with both near infrared spectroscopy optodes mounted on the intact skin of the forehead, while in the remaining eight animals, one near infrared spectroscopy optode was implanted directly on the skull. Near infrared spectroscopy readings at the skin or at the skull differed consiste...Continue Reading

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Citations

Sep 29, 2015·The Journal of Emergency Medicine·Cornelia GenbruggeCathy De Deyne
May 5, 2018·Critical Care Medicine·Krishma AdatiaLucia Rivera-Lara
May 1, 2007·Current Opinion in Critical Care·Peter T Morley
Apr 27, 2007·Pharmaceutical Research·Chandra S ChaurasiaHelen Yeo
Jun 2, 2018·BioMed Research International·J M D van den BruleC W E Hoedemaekers

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