Monitoring of circulating tumor cells and their expression of EGFR/phospho-EGFR during combined radiotherapy regimens in locally advanced squamous cell carcinoma of the head and neck

International Journal of Radiation Oncology, Biology, Physics
Ingeborg TinhoferVolker Budach

Abstract

The numbers of circulating tumor cells (CTCs) and their expression/activation of epidermal growth factor receptor (EGFR) during the course of combined chemo- or bioradiotherapy regimens as potential biomarkers of treatment efficacy in squamous cell carcinoma of the head and neck (SCCHN) were determined. Peripheral blood samples from SCCHN patients with locally advanced stage IVA/B disease who were treated with concurrent radiochemotherapy or induction chemotherapy followed by bioradiation with cetuximab were included in this study. Using flow cytometry, the absolute number of CTCs per defined blood volume as well as their expression of EGFR and its phosphorylated form (pEGFR) during the course of treatment were assessed. Before treatment, we detected ≥1 CTC per 3.75 mL blood in 9 of 31 patients (29%). Basal expression of EGFR was detected in 100% and pEGFR in 55% of the CTC+ cases. The frequency of CTC detection was not influenced by induction chemotherapy. However, the number of CTC+ samples significantly increased after radiotherapy. This radiation-induced increase in CTC numbers was less pronounced when radiotherapy was combined with cetuximab compared to its combination with cisplatin/5-fluorouracil. The former treatment re...Continue Reading

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Citations

Mar 19, 2014·Cancers·Lori E Lowes, Alison L Allan
Jul 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·I TinhoferV Budach
Dec 26, 2015·Bulletin du cancer·Jean-Baptiste GuyNicolas Magné
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Jul 16, 2015·The Journal of Laryngology and Otology·A T HarrisT M Jones
Jan 28, 2014·International Journal of Radiation Biology·Ingeborg TinhoferVolker Budach
Nov 19, 2014·Nature Reviews. Clinical Oncology·Hyunseok KangChristine H Chung
Feb 16, 2017·Scientific Reports·Arutha KulasingheChamindie Punyadeera
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