Monitoring of drug release kinetics from thin polymer films by multi-parametric surface plasmon resonance

International Journal of Pharmaceutics
Kristiina KorhonenRiikka Laitinen

Abstract

The aim of the present study is to monitor the release of perphenazine (PPZ) from thin polymer films in real-time by the multi-parametric surface plasmon resonance method (MP-SPR). The MP-SPR method is capable of measuring changes in polymer films that are significantly thicker than the apparent scanning depth of the SPR field. The in vitro reference measurements confirm that the MP-SPR results can be correlated to the in vitro release of PPZ. However, information gained by MP-SPR can be used to identify three different modes of change in the films with different kinetic timescales, which are not visible in the in vitro testing. The EUDRAGIT(®) RL PO-PVP-PPZ-film shows significantly faster changes than the film without polyvinylpyrroline (PVP). This information can be used to optimize the drug-release profile of different film formulations for different pharmaceutical purposes.

References

Mar 17, 2004·Journal of Pharmaceutical and Biomedical Analysis·A AhmedA F Davis
Oct 19, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·F SiepmannJ Siepmann
Oct 1, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Riikka LaitinenJarkko Ketolainen
Aug 5, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·B GlaesslT Rades
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Jan 29, 2010·International Journal of Pharmaceutics·B GlaesslJ Siepmann
Apr 2, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Xiaomeng LiuOrlando J Rojas
Apr 5, 2011·International Journal of Pharmaceutics·Juergen Siepmann, Nicholas A Peppas
Jun 14, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Niko GranqvistTapani Viitala
Oct 16, 2013·International Journal of Pharmaceutics·Kathrin Nollenberger, Jessica Albers
Apr 29, 2014·Expert Opinion on Drug Delivery·Francesco CilurzoPaola Minghetti
May 27, 2014·International Journal of Pharmaceutics·G Prem KumarD B Raju
Aug 26, 2014·Pharmaceutical Research·Peng LiuLeena Peltonen
Sep 19, 2014·Biomacromolecules·Tamilselvan MohanKarin Stana-Kleinschek
Jan 7, 2015·Critical Reviews in Analytical Chemistry·Andreea OlaruHassan Y Aboul-Enein

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Citations

Mar 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Sara AmorimRicardo A Pires

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