Monitoring of early humoral immunity to identify lung recipients at risk for development of serious infections: A multicenter prospective study

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Elizabeth SarmientoJavier Carbone

Abstract

Infection is still a leading cause of death during the first year after lung transplantation. We performed a multicenter study among teaching hospitals to assess monitoring of early humoral immunity as a means of identifying lung recipients at risk of serious infections. We prospectively analyzed 82 adult lung recipients at 5 centers in Spain. Data were collected before transplantation and at 7 and 30 days after transplantation. Biomarkers included IgG, IgM, IgA, complement factors C3 and C4, titers of antibodies to pneumococcal polysaccharide antigens (IgG, IgA, IgM) and antibodies to cytomegalovirus (IgG), and serum B-cell activating factor (BAFF) levels. The clinical follow-up period lasted 6 months. Clinical outcomes were bacterial infections requiring intravenous anti-microbial agents, cytomegalovirus (CMV) disease, and fungal infections requiring therapy. We found that 33 patients (40.2%) developed at least 1 serious bacterial infection, 8 patients (9.8%) had CMV disease, and 10 patients (12.2%) had fungal infections. Lower IgM antibody levels against pneumococcal polysaccharide antigens at Day 7 (defined as <5 mg/dl) were a risk factor for serious bacterial infection (adjusted odds ratio [OR] 3.96; 95% confidence interva...Continue Reading

Citations

Oct 26, 2018·Reviews in Medical Virology·David NavarroPilar Pérez-Romero
Dec 7, 2018·Breathe·David Abelson, Allan R Glanville
Mar 7, 2020·Expert Review of Vaccines·L HolzerG T Rijkers
Mar 8, 2020·Enfermedades infecciosas y microbiología clínica·Jose Tiago SilvaJosé María Aguado
Oct 17, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Elizabeth SarmientoJavier Carbone
Jul 14, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Hidenao KayawakeHiroshi Date

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The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Elizabeth SarmientoJavier Carbone
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