Monitoring of fed-batch E. coli fermentations with software sensors

Bioprocess and Biosystems Engineering
A C A VelosoE C Ferreira

Abstract

Accurate monitoring and control of industrial bioprocess requires the knowledge of a great number of variables, being some of them not measurable with standard devices. To overcome this difficulty, software sensors can be used for on-line estimation of those variables and, therefore, its development is of paramount importance. An Asymptotic Observer was used for monitoring Escherichia coli fed-batch fermentations. Its performance was evaluated using simulated and experimental data. The results obtained showed that the observer was able to predict the biomass concentration profiles showing, however, less satisfactory results regarding the estimation of glucose and acetate concentrations. In comparison with the results obtained with an Extended Kalman Observer, the performance of the Asymptotic Observer in the fermentation monitoring was slightly better.

References

Jun 23, 2000·Journal of Biotechnology·R NeelemanA J van Boxtel
Mar 8, 2005·Mathematical Biosciences·A Rapaport, D Dochain
Jan 18, 2006·Bioprocess and Biosystems Engineering·M NadriJ Lieto
Feb 28, 2006·Bioprocess and Biosystems Engineering·Marco JenzschAndreas Lübbert
Aug 30, 2007·Bioprocess and Biosystems Engineering·Heléne Sundström, Sven-Olof Enfors
Oct 6, 2007·Bioprocess and Biosystems Engineering·Stefan GnothAndreas Lübbert

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Citations

May 23, 2012·Bioprocess and Biosystems Engineering·Hernán De BattistaJosé Luis Navarro
Jul 28, 2011·Bioprocess and Biosystems Engineering·Joong-Won LeeHang-Sik Shin
Oct 30, 2012·Bioprocess and Biosystems Engineering·Robert Gustavsson, Carl-Fredrik Mandenius
Nov 4, 2021·Preparative Biochemistry & Biotechnology·Mohammad Mahmoodi, Ehsan Nassireslami

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