Monitoring of four dipyrone metabolites in communal wastewater by solid phase extraction liquid chromatography electrospray ionization quadrupole time-of-flight mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis
Zsuzsa Gyenge-SzabóVictor G Mihucz

Abstract

Liquid chromatography quadrupole time-of-flight spectrometry (LC-Q-TOF-MS), equipped with electrospray ionization (ESI), was developed for the determination of the main metabolites of dipyrone - 4-aminoantipyrine (4-AA), 4-acetylaminoantipyrine (4-AAA), 4-formylaminoantipyrine (4-FAA) and 4-methylaminoantipyrine (4-MAA) in communal wastewater after reversed-phase solid phase extraction (SPE) in the low to several μg/l concentration range. Samples originated from conventional wastewater treatment plant (WWTP) using activated sewage sludge as well as from a pilot-scale WWTP operating in mixed mode (activated sewage sludge and cascade biofilms reactors with biofilms growing on fix beds and roots of greenhouse plants). Results of the present study confirmed the outcomes of our previous report according to which, 4-FAA was the most persistent metabolite, while 4-AAA and 4-MAA could be determined in the highest and lowest concentration, respectively. Moreover, the study of intraday variation of the concentration of these metabolites revealed that the concentration of 4-AA, 4-AAA and 4-FAA registered a 46%-75% increase in the samples collected at noon compared to those collected at 6 AM. Chlorination did not affect considerably the re...Continue Reading

References

May 13, 2004·Journal of Pharmaceutical and Biomedical Analysis·Hakan ErgünJacob V Aranda
Sep 20, 2007·European Journal of Mass Spectrometry·Albert Lebedev
Mar 10, 2009·Journal of Hazardous Materials·Belgin GözmenArif Hesenov
Aug 18, 2009·Environmental Toxicology and Chemistry·Maren KahleThomas Poiger

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Citations

Aug 26, 2021·Journal of Veterinary Pharmacology and Therapeutics·İsmet YılmazSelim Erdoğan

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