PMID: 6539490Jan 1, 1984Paper

Monitoring of haloperidol serum levels and it's clinical significance

Progress in Neuro-psychopharmacology & Biological Psychiatry
H ItohK Ichikawa

Abstract

Haloperidol serum levels were determined by the recently developed radioimmunoassay technique to elucidate the relationship between serum levels and clinical effects and that between serum levels and adverse effects. The serum levels of haloperidol in divided daily doses schedule reached to the steady state more rapidly (within 7 days) than in single dose schedule. The single daily dose schedule showed significantly wider diurnal variation than the divided daily doses schedule. No remarkable differences in serum concentration was noted between different types of oral haloperidol preparation (liquid, granule, tablet). No definite relationship was established between the serum concentration of haloperidol and incidence of tardive dyskinesia. No definite positive relationship between clinical effects and serum concentration of haloperidol could obtained.

References

Jul 1, 1976·Pharmakopsychiatrie, Neuro-Psychopharmakologie·M Lader
Jan 1, 1974·European Journal of Clinical Pharmacology·W A CressmanJ Plostnieks
Jan 1, 1980·Progress in Neuro-psychopharmacology·H ItohK Ichikawa

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Citations

Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·J L SantosJ A Cabranes
Apr 1, 1989·Acta Psychiatrica Scandinavica·J L SantosF Angeles
Aug 16, 2016·Postgraduate Medical Journal·Ko-Chin ChenAndrew G Christy
Dec 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·H CambonB Maziere
May 1, 1988·Drug Intelligence & Clinical Pharmacy·J J SramekR Hahn

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