Monitoring of human exposure to carcinogens through DNA and protein adduct determination

Toxicology Letters
P B Farmer

Abstract

For genotoxic carcinogens, exposure assessment may be achieved by measurements of the extent of covalent interaction (adduct formation) that has occurred between the carcinogen and macromolecules such as DNA, haemoglobin and albumin. Adducts for many carcinogens have been found in supposedly unexposed populations. This signifies either that endogenous processes contribute to this DNA/protein modification, or that there are exogenous exposures to these carcinogens that were not previously recognised. Notable examples where 'background' genotoxic modification has been found include damage caused by low molecular weight alkylating agents and hydroxyl radicals. The significance of the existence of these adducts to genotoxic risk is as yet unknown.

References

Jan 1, 1992·Free Radical Research Communications·B Halliwell, M Dizdaroglu
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J R WagnerB N Ames
Jul 1, 1992·Carcinogenesis·A C Beach, R C Gupta
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R CathcartB N Ames
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K RanderathR C Gupta

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Citations

Apr 27, 2001·Toxicology Letters·B Heinrich-HirschU Gundert-Remy
Dec 1, 1996·Human & Experimental Toxicology·P Farmer
Oct 7, 2004·Environmental and Molecular Mutagenesis·Lode GodderisDominique Lison
Dec 1, 2007·Proteomics. Clinical Applications·Yue GeRussell D Owen
Dec 9, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Joachim D Pleil, Linda S Sheldon

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