PMID: 9434878Jan 22, 1998Paper

Monitoring of occupational exposure to epichlorohydrin by genetic effects and hemoglobin adducts

Mutation Research
H Hindsq LandinA Tates

Abstract

The present work is focused on the determination of in vivo doses and studies of genetic effects in workers exposed to epichlorohydrin (ECH). The studied endpoints were hemoglobin (Hb) adducts, frequencies of hprt mutants, micronuclei in cytochalasin B blocked binucleated lymphocytes, sister chromatid exchanges (SCE) and high frequency cells (HFC). Blood samples were collected from office clerks and ECH exposed factory workers at an industrial plant in Germany. The workers were exposed to 0.11-0.23 ppm ECH in the air 45 h per week and to 0.2-2.6 ppm for 3 h per week. Some Swedish non-exposed subjects were also used for Hb adduct measurements. The genetic data, HFC and SCE, showed a significant difference between exposed and unexposed donors. In contrast to earlier studies on SCE, no impact of smoking was observed. Effects on micronuclei were on the borderline of significance, whereas there was no effect for HPRT mutants. The average Hb adduct level was higher in exposed than in non-exposed donors, although the difference was only significant when the exposed group was compared to Swedish controls. Smoking gave significantly increased adduct levels. The absence of significant correlations between individual data for Hb adducts a...Continue Reading

References

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Citations

May 8, 2013·Archives of Toxicology·Klaus E AppelAlfonso Lampen
Apr 6, 1999·Chemico-biological Interactions·H H LandinS Osterman-Golkar
Oct 19, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H Hindsø LandinM Törnqvist
Oct 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M TörnqvistP Rydberg
Jan 29, 2014·Toxicology and Applied Pharmacology·Hiroshi HondaToshio Kasamatsu
Aug 15, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hiroshi HondaToshio Kasamatsu
Jul 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hiroshi HondaToshio Kasamatsu
Jan 6, 2018·Archives of Toxicology·Ivonne M C M RietjensGerhard Eisenbrand
Oct 29, 2014·Chemical Research in Toxicology·Henrik CarlssonMargareta Törnqvist

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