Monitoring of rheologic variables during postoperative high-dose brachytherapy for uterine cancer

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
G F von TempelhoffGerhard Hommel

Abstract

Oxygenation of tumor tissue has recently been assed an important prerequisite for the effectiveness of radiotherapy in cervical cancer. Hyperviscosity is a common phenomenon in malignancy and a cause of reduced oxygen transport capacity that would favour tissue hypoxia. Hemorheological variables were serially tested preoperatively, during four cycles of fractionated adjuvant IR(192) HDR after loading radiation (HDR-AL) of the vaginal vault (weekly intervals), and 6 months postoperatively in patients with cervical (n=12) and endometrial cancer (n=26). Women who were scheduled for benign tumor surgery served as controls (n=29). Preoperatively, in cervical and endometrial cancer patients, mean plasma viscosity (PV: 1.31+/-0.1 mPa s; p<0.05; 1.35+/-0.13 mPa s; p<0.001) and fibrinogen levels (383+/-46 mg/dL; p<0.05; 379+/-117 mg/dL; p<0.05) were higher as compared to the controls (1.25+/-0.07 mPa s; 314+/-89 mg/dL). Red blood cell aggregation at low shear and stasis (RBC agg.: 15.7+/-5.6; p<0.05; 29.6+/-9.1; p<0.05) was higher in endometrial cancer patients as compared to the controls (13.7+/-3.4; 25.3+/-5.6). Postoperatively PV decreased in endometrial cancer patients and transiently increased in cervical cancer patients. After the...Continue Reading

References

Jul 1, 1992·The Journal of Bone and Joint Surgery. British Volume·R R ChoudhryP J Gregg
May 1, 1989·Gynecologic Oncology·B Miller, L Heilmann
Nov 1, 1983·Biomedizinische Technik. Biomedical Engineering·F JungH Kiesewetter
Sep 1, 1994·Progress in Cardiovascular Diseases·G F Pineo, R D Hull
Jul 31, 1998·Thrombosis Research·G F von TempelhoffL Heilmann
Aug 12, 1998·International Journal of Cancer. Journal International Du Cancer·M HöckelP Vaupel
Feb 5, 2000·Advances in Experimental Medicine and Biology·P Vaupel, M Hoeckel
Feb 9, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T H KnockeR Pötter
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A FylesR P Hill
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·M N LevineA K Kakkar

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Citations

Nov 2, 2005·Journal of Thrombosis and Thrombolysis·Richard C Becker
Mar 7, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·X WangJ J Kavanagh
May 16, 2018·Clinical Hemorheology and Microcirculation·Panagiotis TsikourasRoland Csorba

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