Oct 18, 2013

Monitoring of viral pathogens in pediatric intensive care unit and analysis of clinical significance

Zhonghua er ke za zhi. Chinese journal of pediatrics
Xiao-ying CaiZe-xi Xiao

Abstract

To study the characteristics of viral spectrum and clinical features of children in pediatric intensive care unit (PICU). Nasopharyngeal aspirate specimens (NPA) from 349 patients(1 from each) and 130 cerebrospinal fluids (CSF) specimens were collected from children who were admitted to the PICU of Second Affiliated Hospital of Shantou University Medical College. Additional 87 NPA specimens were collected from healthy children for routine examination on the physical examination center, and the clinical data were collected. Multiplex PCR was applied to detect 16 kinds of viruses from NPA and CSF. Fluorescence quantitative PCR was applied to detect 13 viruses from CSF and to analyze the clinical data of positive cases. There were 209 samples (59.9%) of the 349 NPA specimens were positive for viruses, which included 117 cases positive for human rhinovirus (HRV), 60 for respiratory syncytial virus (RSV), 20 for influenza virus A (Inf A), 10 for adenovirus (ADV), 6 for parainfluenza virus type 3(PIV-3), 6 for human Boca virus (HBoV), 5 for influenza virus C(Inf C), 4 for parainfluenza virus type 4(PIV-4), 4 for human coronavirus-HKU1/OC43, 3 for influenza virus B (Inf B), 3 for WU Polyomavirus (WUPyV), 2 parainfluenza virus type 1(P...Continue Reading

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Mentioned in this Paper

Viral Encephalitis
Tumor Virus Infections
Respiratory Syncytial Virus Infections
Pediatric Intensive Care Unit
Influenzavirus A antigen
Human coronavirus
Virus Diseases
Pathogenic Organism
RNA Viruses
MESDC2 wt Allele

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