PMID: 14642913Dec 4, 2003Paper

Monitoring of water content and water distribution in ischemic hearts

Michael SchaeferMartha Maria Gebhard


We determined water content and water distribution by fitting dielectric spectra of ischemic canine hearts between 5 MHz and 3 GHz with a newly developed model which describes heart cells and subcellular organelles as rotational ellipsoids filled with electrolyte enclosed by an isolating membrane. The fraction of dry material is modelled by spherical particles with a small dielectric permittivity. Free model parameters were water content, cell volume fraction, and the conductivity of the electrolytes. Resulting model parameters were compared to data from tissue desiccation and to conductivity changes produced by protons and lactate ions. We investigated hearts in two states: during ischemia after interruption of blood flow (pure ischemia, PI, n=5) and during ischemia after resuscitation with Tyrode's solution (IAR, n=14). The difference between water content determined by tissue desiccation and by dielectric spectroscopy was less than 0.5%. During 360 min of ischemia, water content in IAR decreased from 85+/-1.6% to 83+/-2.2% and in PI from 80+/-0.8% to 78+/-1.5%. Cellular volume fraction in IAR increased from 0.47+/-0.045 to 0.63+/-0.031 and in PI from 0.62+/-0.014 to 0.73+/-0.013, which is consistent with published morphometr...Continue Reading


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Apr 16, 1998·The Journal of Thoracic and Cardiovascular Surgery·A B EricssonJ Vaage
Jun 18, 1999·Annals of the New York Academy of Sciences·J Jossinet, M Schmitt
Jun 18, 1999·Annals of the New York Academy of Sciences·B J ThomasA Jacobs
Mar 20, 2001·Critical Care : the Official Journal of the Critical Care Forum·U Kreimeier
Jan 31, 2002·Journal of Biomedical Optics·A E CerussiB J Tromberg
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jérôme BadautLuca Regli
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Jan 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·K BendjelidM Janier


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