Monitoring people at risk of drinking by a rapid urinary ethyl glucuronide test

Interdisciplinary Toxicology
Nadia FucciCristiana Gambelunghe

Abstract

Alcohol and illicit drug abuse are major public health problems worldwide. Since alcohol is the predominant substance of choice in polydrug abusers, monitoring its use, along with urinary drug screening in patients in rehabilitation programs, appeared to be crucial in identifying patients at risk of alcohol disorders leading to impaired quality of life. Ethyl β-D-6-glucuronide, a non-oxidative, non-volatile, stable and minor direct ethanol metabolite, has a 6h to 4 day window of detection in urine after the last alcohol intake. Each of the 119 subjects (85 males, 34 females) registered with the Public Health Service for Drug Dependence Treatment provided a urine sample for ethylglucoronide (EtG) determination in an immunochemical test with a 500 ng/ml cutoff. All results were evaluated with confirmation criteria of a fully validated gas chromatography/mass spectrometry assay. The diagnostic performance of the EtG immunochemical test was assessed using Receiver Operating Characteristic Curve analysis. The immunochemical test specificity was 100% for EtG urinary values above 500 ng/ml. No false positive results were found. With levels below 500 ng/ml, 12% of the samples were classified as negative. The average consumption of the ...Continue Reading

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Citations

Nov 2, 2019·Biosensors·Paloma Yáñez-SedeñoJosé Manuel Pingarrón
Jan 14, 2021·Basic & Clinical Pharmacology & Toxicology·Nete Lundager Klokker RausgaardPer Damkier
Mar 7, 2021·International Journal of Environmental Research and Public Health·Alessio GiliCristiana Gambelunghe
Jun 14, 2019·Visceral Medicine·Alexander WaldthalerJ-Matthias Löhr

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