Monitoring peripheral blood CD4+ adenosine triphosphate activity in recurrent hepatitis C and its correlation to fibrosis progression

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Naim AlkhouriN N Zein

Abstract

The recurrence of hepatitis C virus (HCV) after orthotopic liver transplantation (OLT) is often associated with rapid fibrosis progression attributed to the state of impaired cellular immunity. At present, there are no means to predict those at risk for progression. Peripheral blood CD4+ adenosine triphosphate (ATP) release (the ImmuKnow assay) correlates with immunoreactivity and has been used to monitor global cellular immune function in transplant recipients. The aim of this study was to assess the relationship between cellular immune function measured by the ImmuKnow assay and fibrosis progression in patients with HCV recurrence after OLT. The ImmuKnow assay was prospectively performed in adult HCV patients at 4 and 12 months post-OLT. Protocol liver biopsies were performed (on day 7, in month 4, and yearly) after OLT. The first biopsy that showed fibrosis post-OLT was used to determine the time interval for developing fibrosis. Sixty-two patients met the inclusion criteria. The median follow-up time was 12 (6.5-12.1) months. Fibrosis progression was observed in 61.3% of the patients. ATP levels were lower in patients with fibrosis progression in comparison with patients without progression at 4 months (145 versus 259 ng/mL...Continue Reading

References

Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A SheinerC M Miller
Jan 1, 1996·Gastroenterology·J GournayJ R Lake
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Aug 15, 1996·The New England Journal of Medicine·M A Heneghan
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M CharltonJ Hoofnagle
Mar 31, 2000·Immunology Today·F ButtgereitM D Brand
Oct 4, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina Berenguer
Sep 17, 2003·The Journal of Clinical Investigation·Cheryl L DayKai W Wucherpfennig
Oct 31, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mitchell L ShiffmanGregory T Everson
Jan 27, 2004·Transplantation·Ulf P NeumannPeter Neuhaus
Dec 25, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Scott J WestonHugo R Rosen
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nasser SemmoPaul Klenerman
Jul 19, 2005·Clinics in Liver Disease·Scott W Biggins, Norah A Terrault
Aug 19, 2005·Nature·David G Bowen, Christopher M Walker
Aug 19, 2005·Nature·Robert S Brown
Aug 27, 2005·The Lancet Infectious Diseases·Colin W ShepardMiriam J Alter
Mar 24, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jan Michael LangrehrUlf Peter Neumann
Mar 21, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luca S BelliGiovambattista Pinzello
Jun 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nevin YilmazRobert A Fisher
Sep 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Atul HumarUNKNOWN PV16000 Study Group
Dec 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hugo R RosenLucy Golden-Mason
May 13, 2008·Gastroenterology·Sandeep Mukherjee, Michael F Sorrell
Aug 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ibrahim A HanounehNizar N Zein
Aug 30, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michel MendlerOkechukwu Ojogho
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Edward J Gane
Oct 28, 2008·Biological Chemistry·Robert ThimmeHubert E Blum

❮ Previous
Next ❯

Citations

Feb 8, 2013·Clinical and Vaccine Immunology : CVI·Russell M YeeJames C Ryan
Nov 26, 2013·Purinergic Signalling·Geoffrey BurnstockSimon C Robson
Mar 27, 2012·Current Hepatitis Reports·A Sidney BarrittPaul H Hayashi
Jun 29, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emilio RodrigoManuel Arias
May 5, 2012·Clinical Transplantation·Helen S TeDonald M Jensen
Jul 16, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Josh Levitsky
Jun 4, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shunji NagaiDilip Moonka
Jul 3, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Helen S Te
Aug 30, 2014·World Journal of Gastroenterology : WJG·Alberto Grassi, Giorgio Ballardini
Mar 19, 2014·Transplantation·Shunji NagaiAtsushi Yoshida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Michel MendlerOkechukwu Ojogho
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Roniel CabreraGiuseppe Morelli
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Ibrahim A HanounehN N Zein
© 2021 Meta ULC. All rights reserved