Monitoring Progression of Amyotrophic Lateral Sclerosis Using Ultrasound Morpho-Textural Muscle Biomarkers: A Pilot Study

Ultrasound in Medicine & Biology
Jacinto J Martínez-PayáMaría Elena Del Baño-Aledo

Abstract

The need is increasing for progression biomarkers that allow the loss of motor neurons in amyotrophic lateral sclerosis (ALS) to be monitored in clinical trials. In this prospective longitudinal study, muscle thickness, echointensity, echovariation and gray level co-occurrence matrix textural features are examined as possible progression ultrasound biomarkers in ALS patients during a 5-mo follow-up period. We subjected 13 patients to 3 measurements for 20 wk. They showed a significant loss of muscle, an evident tendency to loss of thickness and increased echointensity and echovariation. In regard to textural parameters, muscle heterogeneity tended to increase as a result of the neoformation of non-contractile tissue through denervation. Considering some limitations of the study, the quantitative muscle ultrasound biomarkers evaluated showed a promising ability to monitor patients affected by ALS.

Citations

Nov 15, 2018·International Journal of Environmental Research and Public Health·Cesar Calvo-LoboDaniel López-López
Oct 20, 2018·Muscle & Nerve·Sapna PathakMichael S Cartwright
Jan 23, 2019·European Radiology·José Ríos-DíazJacinto J Martínez-Payá
Jun 15, 2019·International Journal of Molecular Sciences·Laura Moreno-MartinezRosario Osta
Jan 17, 2021·Ultrasound in Medicine & Biology·Michael T Paris, Marina Mourtzakis
Mar 7, 2021·International Journal of Environmental Research and Public Health·Blanca De-la-Cruz-TorresCarlos Romero-Morales
Jul 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Tsun-Haw TohNortina Shahrizaila
Aug 26, 2021·International Journal of General Medicine·Andrew HannafordNeil G Simon

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Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.

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